期刊
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
卷 63, 期 1, 页码 148-150出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1574-695X.2011.00829.x
关键词
Candida albicans; retinal microglia; Dectin-1; TLR2; phagocytosis; flow cytometry
资金
- Generalitat Valenciana [ACOMP/2011/134]
- Ministerio de Ciencia e Innovacion, Instituto de Salud Carlos III [RETICS RD07/0062/0012]
- Fundacion Medica Mutua Madrilena
We have investigated the expression of TLR2 and Dectin-1 in retinal microglia and their involvement in Candida albicans phagocytosis using a cytometric approach. The expression of both receptors has been demonstrated in CD11b(+) retinal cells. Phagocytosis of pHrodo-labelled C. albicans yeasts by microglial CD11b(+) cells of C57BL/6 mice was inhibited both by the Dectin-1 antagonist laminarin and anti-Dectin-1 antibodies, whereas phagocytosis of yeasts by retinal microglia of TLR2 KO mice was unaffected. These data indicate that phagocytosis of C. albicans yeasts by retinal microglia is mediated by Dectin-1, whereas TLR2 does not play a significant role in this process.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据