Article
Immunology
Ya-li Yang, Yi-bin Fan, Lei Gao, Chao Zhang, Ju-lin Gu, Wei-hua Pan, Wei Fang
Summary: This study elucidates the role of Csn1201 protein in cryptococcal fitness and host immunity. Deletion of Csn1201 blocks the pulmonary infection and extrapulmonary dissemination of Cryptococcus neoformans, while enhancing the host immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Immunology
Gustavo J. C. Freitas, Daniel A. Santos
Summary: Understanding the role of CP in inhibiting CD11b recognition of C. gattii can provide valuable information for diagnosing, preventing, and treating cryptococcosis. Deeply understanding the role of C. gattii during infection is crucial for influencing strategies in developing new vaccines against cryptococcosis.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Review
Oncology
Hongtai Xiong, Xinpu Han, Liu Cai, Honggang Zheng
Summary: This paper discusses the mechanisms of polysaccharides in tumor immunotherapy and their relationship with dendritic cells. The research shows that polysaccharides can promote the maturation, antigen presentation, and activation of T cells of dendritic cells by activating signaling pathways, thereby exerting an anti-tumor effect. In addition, polysaccharides can also be used as adjuvants for DC vaccines, combined with other immunotherapies and nano drug delivery systems for cancer immunotherapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Matthew T. Henke, Eric M. Brown, Chelsi D. Cassilly, Hera Vlamakis, Ramnik J. Xavier, Jon Clardy
Summary: Research has shown that some isolates of R. gnavus produce a capsular polysaccharide that promotes tolerogenic immune responses, while isolates lacking a capsule trigger robust proinflammatory responses. In mouse experiments, it was also found that mice colonized with an isolate of R. gnavus lacking a capsule showed increased gut inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Urology & Nephrology
Xiaoyang Wang, Robert Lopez, Rebecca A. Luchtel, Sassan Hafizi, Benjamin Gartrell, Niraj Shenoy
Summary: This article reviews the advancements in targeted therapies and immune checkpoint inhibitors in the treatment landscape of Renal Cell Carcinoma (RCC) over the last decade, emphasizing the importance of understanding the mechanisms adopted by RCC cells to evade immune killing and exploring current clinical trials and future directions in the field.
KIDNEY INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Marco Fangazio, Erik Ladewig, Karen Gomez, Laura Garcia-Ibanez, Rahul Kumar, Julie Teruya-Feldstein, Davide Rossi, Ioan Filip, Qiang Pan-Hammarstrom, Giorgio Inghirami, Renzo Boldorini, German Ott, Annette M. Staiger, Bjorn Chapuy, Gianluca Gaidano, Govind Bhagat, Katia Basso, Raul Rabadan, Laura Pasqualucci, Riccardo Dalla-Favera
Summary: The loss of MHC-I in DLBCL is associated with somatic inactivation of HLA-I loci and has a significant impact on neoantigen and mutational burden. There is a multistep process of HLA-I loss in DLBCL development involving both germline and somatic events.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Julie Cagliero, Frederique Vernel-Pauillac, Gerald Murray, Ben Adler, Mariko Matsui, Catherine Werts
Summary: Leptospira interrogans is a bacterial species causing a globally neglected zoonotic disease, with highly immunogenic LPS as a crucial feature.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Katarina Pinjusic, Olivier Andreas Dubey, Olga Egorova, Sina Nassiri, Etienne Meylan, Julien Faget, Daniel Beat Constam
Summary: This study reveals that Activin-A secretion by melanoma cells inhibits adaptive antitumor immunity by indirectly inhibiting CD8(+) T cell infiltration, regardless of BRAF status. It is also found that Activin-A/INHBA expression is correlated with resistance to anti-PD1 therapy in melanoma patients and impairs response to combination anti-cytotoxic T-Lymphocyte associated protein 4/anti-PD1 treatment in preclinical models.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Microbiology
Yonathan Arfi, Carole Lartigue, Pascal Sirand-Pugnet, Alain Blanchard
Summary: Mycoplasmas are small, genome-reduced bacteria with the ability to colonize a wide range of host species. They can exist as commensal microbiota or cause pathogenic inflammatory diseases. These bacteria have evolved strategies to evade the host's immune response, including the expression of immunoglobulin-binding proteins to prevent antibody-antigen interaction. Understanding these immune evasion mechanisms is crucial for studying mycoplasma diseases and improving vaccine efficacy.
Article
Biotechnology & Applied Microbiology
Ying Chen, Meilian Zhao, Dongliang Shen, Qian Yi, Liling Tang
Summary: SNF5 is overexpressed in non-small cell lung cancer (NSCLC), promoting tumor cell proliferation and immune evasion. It regulates immune evasion in NSCLC cells by activating the STAT3/phospho-STAT3 pathway.
Article
Multidisciplinary Sciences
Rana Falahat, Anders Berglund, Ryan M. Putney, Patricio Perez-Villarroel, Shota Aoyama, Shari Pilon-Thomas, Glen N. Barber, James J. Mule
Summary: The lack or loss of tumor antigenicity is a key mechanism of immune evasion and resistance to T cell-based immunotherapies. Epigenetic regulation, specifically DNA methylation, plays a role in suppressing the STING signaling function in melanoma cells, but this suppression can be reversed through pharmacologic DNA methylation inhibition. Restoring STING signaling improves melanoma cell antigenicity and enhances recognition and killing by cytotoxic T cells, highlighting the functional significance of epigenetic processes in tumor-immune evasion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Ningning Niu, Xuqing Shen, Li Zhang, Yueyue Chen, Ping Lu, Wenjuan Yang, Mingzhu Liu, Juanjuan Shi, Dapeng Xu, Yingying Tang, Xiaotong Yang, Yawen Weng, Xinxin Zhao, Lian-Ming Wu, Yongwei Sun, Jing Xue
Summary: This study reveals how Setd2 deficiency in pancreatic cancer reprograms neutrophils to an immunosuppressive phenotype, promoting immune escape. Mechanistically, Setd2 deficiency leads to the gain of H3K27me3, which downregulates CXADR expression, activating the PI3K-AKT pathway and excessive expression of CXCL1 and GM-CSF, thereby promoting neutrophil recruitment and reprogramming.
Article
Microbiology
Philip T. Lange, Blossom Damania
Summary: EBV is a common pathogen that causes significant lymphoma burden worldwide. In the treatment of EBV-driven lymphoma, targeting the purinergic signaling pathway may be a promising immunotherapeutic target.
Article
Immunology
Jessica Helen dos Santos Carvalho, Jeana Karen Castro Nascimento, Kassia Gabriela Vieira Silva, Sebastiao Silveira Neto, Alessandra Teixeira de Macedo, Hermeson Lima Franca, Larissa dos Reis Ferreira, Rayssa de Sousa Silva, Joicy Cortez Sa, Diego Gomes Ramos, Daniela de Araujo Viana Marques, Cinthia Furst, Daniel Assis Santos, Julliana Ribeiro Alves Santos, Rodrigo Assuncao Holanda
Summary: The virulence of Cryptococcus spp. can be regulated by the interaction with abiotic and biotic factors in the natural environment. This study evaluated the impact of prior interaction between highly virulent Cryptococcus gattii strain R265 and Acanthamoeba castellanii on the progression of cryptococcosis. The results showed that the interaction between yeast and amoeba altered yeast phenotype, polysaccharide secretion, and oxidative stress tolerance, thus influencing the progression of cryptococcal infection.
MICROBES AND INFECTION
(2023)
Article
Chemistry, Physical
Guixiang Xu, Kai Liu, Xiangwu Chen, Yang Lin, Cancan Yu, Xinxin Nie, Wenxiu He, Nathan Karin, Yuxia Luan
Summary: An injectable hydrogel was designed to reinforce cancer immunotherapy by regulating CXCL10 degradation to amplify tumor T cell infiltration and inactivating PD-L1 to eliminate the PD-L1-governed immune evasion.
NANOSCALE HORIZONS
(2023)
Letter
Infectious Diseases
Lei Zha, Ya Shen, Lingling Pan, Mingfeng Han, Gang Yang, Xiaobao Teng, Boris Tefsen
JOURNAL OF INFECTION
(2021)
Review
Biology
Moujian Guo, Lixia Hui, Yiwen Nie, Boris Tefsen, Ying Wu
Summary: The re-emergence of Zika virus has led to a global health emergency due to its association with neonatal microcephaly and Guillain-Barre syndrome. Recent studies have identified the roles of various viral proteins in Zika virus infection, providing insights for treatment and prevention strategies. Research on the interactions between Zika virus proteins and host factors has advanced our understanding of the virus's pathogenicity.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Review
Microbiology
Maritza Torres, Hans de Cock, Adriana Marcela Celis Ramirez
Article
Engineering, Environmental
Boling Li, Xiaokai Zhang, Jianming Deng, Yili Cheng, Zheng Chen, Boqiang Qin, Boris Tefsen, Mona Wells
Summary: Little work has been done on the role of micronutrients in influencing harmful algal blooms, yet they are essential for growth. This study investigates the effects of copper, iron, and copper-iron amendments on algal growth and production of certain compounds, providing new insights into micronutrient dynamics in aquatic environments.
Article
Infectious Diseases
Lei Zha, Dayan Zhang, Lingling Pan, Zhichu Ren, Xiang Li, Yi Zou, Shirong Li, Shuangqi Luo, Gang Yang, Boris Tefsen
Summary: Tigecycline showed lower clinical and microbiological cure rates compared to fluoroquinolones in treating Stenotrophomonas maltophilia ventilator-associated pneumonia (VAP), but did not result in increased 28-day mortality. Therefore, the use of standard dose tigecycline in treating S. maltophilia VAP is not recommended due to unfavorable clinical outcomes unless new clinical evidence emerges.
INFECTIOUS DISEASES AND THERAPY
(2021)
Article
Psychiatry
Lingling Pan, Qiancheng Xu, Xia Kuang, Xiancui Zhang, Fengxia Fang, Liling Gui, Mei Li, Boris Tefsen, Lei Zha, Huan Liu
Summary: The study found that 8 months after the end of the outbreak, the prevalence of PTSD among healthcare workers exposed to COVID-19 in Wuhan remained high, with symptoms including shortened sleeping time, feelings of loneliness, decreased quality of life, and intention to resign. Risk factors for PTSD included comorbid chronic disease, social isolation, and job dissatisfaction, while protective factors included adequate COVID-19 information, good family function, and working in well-prepared mobile cabin hospitals.
Letter
Infectious Diseases
Lei Zha, Shirong Li, Zhichu Ren, Xiang Li, Dayan Zhang, Yi Zou, Lingling Pan, Qiancheng Xu, Zuqin Rui, Shanghua Chen, Gang Yang, Zhixiang Chen, Boris Tefsen, Jun Guo
JOURNAL OF INFECTION
(2022)
Article
Environmental Sciences
Xiaokai Zhang, Boling Li, Daniel N. Schillereff, Richard C. Chiverrell, Boris Tefsen, Mona Wells
Summary: The study investigates the impact of soil/sediment on bioreporter signals, highlighting the importance of considering this when assessing pollutant bioavailability. Neglecting this effect can lead to significant errors in results. Recommendations for different experimental settings were provided to ensure accurate measurements.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Engineering, Environmental
Boling Li, Xiaokai Zhang, Boris Tefsen, Mona Wells
Summary: Due to the large number of contaminated sites, bioavailability-based measurement and modeling of toxicity are used for screening response, although they are relatively cumbersome. This study demonstrates the use of high throughput lights-on bioreporter technology to measure both speciation and toxicity of cadmium and lead. The bioreporter has a strong predictive ability for toxicity endpoints, making it useful for assessing the risk of aquatic ecotoxicity and setting environmental water quality standards.
Review
Microbiology
Kim Verburg, Jacq van Neer, Margherita Duca, Hans de Cock
Summary: Germination of conidia is a critical process in the Aspergillus life cycle and plays a major role in host infection. Targeting germination with novel antifungals could lead to early intervention and decreased fungal burden on patients.
Editorial Material
Engineering, Environmental
Xiaokai Zhang, Damia Barcelo, Robert J. Clougherty, Bin Gao, Hauke Harms, Boris Tefsen, Meththika Vithanage, Hailong Wang, Zhenyu Wang, Mona Wells
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Infectious Diseases
Lei Zha, Xiang Li, Zhichu Ren, Dayan Zhang, Yi Zou, Lingling Pan, Shirong Li, Shanghua Chen, Boris Tefsen
Summary: Based on a retrospective cohort study, piperacillin/tazobactam could be an effective alternative to carbapenems for treating nosocomial pneumonia caused by ESBL-producing K. pneumoniae when the minimum inhibitory concentration (MIC) is <= 8 mg/L.
Article
Biochemistry & Molecular Biology
Trillion Surya Lioe, Ziwen Xie, Jianfang Wu, Wenlong Li, Li Sun, Qiaoli Feng, Raju Sekar, Boris Tefsen, David Ruiz-Carrillo
Summary: In this study, we identified and characterized a dipeptidyl peptidase from Mycobacterium tuberculosis (MtDPP) that specifically cleaves proline residues at the P-1 substrate position and exhibits high thermal stability. We also found that alanine replacements of residues in the active site of MtDPP resulted in loss of catalysis. Furthermore, we demonstrated that MtDPP activity is inhibited by known DPP4 inhibitors and can truncate the C-X-C motif chemokine ligand 10, suggesting a potential role in immune modulation for this mycobacterial enzyme.
BIOLOGICAL CHEMISTRY
(2023)
Article
Engineering, Chemical
Paul Craig, Ruben Ng, Boris Tefsen, Sam Linsen, Yu Liu, Joshua Hendel
Summary: Biochips are engineered substrates that change colour according to biochemical reactions, and can detect multiple analytes simultaneously. Chip designs that use a combination of spots are more efficient but challenging to design. This study explores the potential of information visualization and machine learning techniques to improve biochip design.
Article
Infectious Diseases
Lei Zha, Xue Zhang, Yusheng Cheng, Qiancheng Xu, Lingxi Liu, Simin Chen, Zhiwei Lu, Jun Guo, Boris Tefsen
Summary: The benefit of combining polymyxin and tigecycline for treating carbapenem-resistant bacterial infections is uncertain. A cohort study found that adding polymyxin B to high-dose tigecycline therapy did not lead to better clinical outcomes in pneumonia patients caused by carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii. The study recommended against adding polymyxin B to the high-dose tigecycline regimen for this type of pneumonia.