Article
Biochemistry & Molecular Biology
Dhruv C. Rathod, Sonali M. Vaidya, Marie-T. Hopp, Toni Kuehl, Diana Imhof
Summary: Heme plays a dual role in biological processes, functioning as a prosthetic group of hemoproteins and also regulating biochemical pathways through transient association with proteins. However, the mechanisms of heme recognition and complex formation with target proteins are poorly understood. This report focuses on evaluating mammalian heme-regulated proteins and their heme-binding motifs (HBMs), particularly the Cys-Pro dipeptide motifs. This analysis provides insights into the sequence and structural anomalies observed during transient heme binding and protein regulation.
Article
Biochemical Research Methods
Ran Liu, Ye-Fan Hu, Jian-Dong Huang, Xiaodan Fan
Summary: A Bayesian model is proposed to jointly infer core locations, binding affinity, and binding thresholds, providing accurate determination for each MHC. Simulation studies showed desirable estimation accuracy and robustness of the model, outperforming commonly used thresholds when applied to real data.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Biochemistry & Molecular Biology
Andrea Eisenreichova, Evzen Boura
Summary: This article reports the crystal structure of the complex formed by SARS-CoV-2 nucleocapsid protein and 14-3-3 protein, revealing the details of the binding. The study found that the N protein forms a complex with 14-3-3 protein through phosphorylation, and the central binding groove of 14-3-3 protein plays a key role. These findings enhance our understanding of the viral infection mechanism.
JOURNAL OF STRUCTURAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Roberto Marabini, Gabriela N. Condezo, Mart Krupovic, Rosa Menendez-Conejero, Josue Gomez-Blanco, Carmen San Martin
Summary: This study presents the high-resolution structure of lizard atadenovirus LAdV-2, highlighting significant structural differences between mastadenoviruses infecting mammals and atadenoviruses infecting non-mammalian hosts. The identification of genus-specific proteins LH2, p32k, and LH3 provides insights into the evolution of adenoviruses, with implications for capsid-binding motifs and gene duplication events. The exaptation of mastadenovirus E1B-55 K from the atadenovirus-like LH3 protein underscores the importance of minor coat proteins in determining specific physicochemical properties and tropism of viruses.
Article
Immunology
Zeynep Kosaloglu-Yalcin, John Sidney, William Chronister, Bjoern Peters, Alessandro Sette
Summary: Binding prediction tools are commonly used in identifying peptides presented on MHC class II molecules, but discrepancies between ligand elution data and binding predictions have been reported. While most MHC class II eluted ligands are predicted to bind with high affinity, there are instances where an increased number of ligands not predicted to bind were found due to ambiguous MHC restrictions. Additional analyses also showed that ligands predicted to not bind may bind other co-expressed MHC class II molecules.
Review
Biochemistry & Molecular Biology
Alice Romagnoli, Mattia D'Agostino, Chiara Ardiccioni, Cristina Maracci, Stefano Motta, Anna La Teana, Daniele Di Marino
Summary: eIF4E plays a central role in controlling mRNA translation, with its interaction with eIF4G and 4E-BPs being crucial for the assembly of the translational machinery. Recent discoveries of non-canonical binding motifs could have implications for the development of new therapeutic strategies targeting eIF4E.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Immunology
Yan Fang, Pengcheng Sun, Xuping Xie, Mingjian Du, Fenghe Du, Jianfeng Ye, Birte K. Kalveram, Jessica A. Plante, Kenneth S. Plante, Bo Li, Xiao-chen Bai, Pei-Yong Shi, Zhijian J. Chen
Summary: The study utilized LIBRA-seq technology to identify an antibody, SW186, that exhibits broad neutralizing activity against various SARS-CoV-2 variants. The cryo-EM structure analysis revealed that SW186 targets a conserved epitope on the receptor binding domain of the viral spike protein. In mouse models, administration of SW186 significantly reduced viral loads in the lungs.
SCIENCE IMMUNOLOGY
(2022)
Review
Oncology
Yingshu Cao, Xin Di, Qinghua Zhang, Ranwei Li, Ke Wang
Summary: RBM10 is a RNA-binding motif protein involved in alternative splicing and mRNA post-transcriptional modification. It has been found to be abnormally expressed in various malignant tumors and has dual effects of inhibiting and promoting cancer growth.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Medicinal
Zizhen Zhao, Xiaorong Li, Zhihong Cui, Tingting Tong, Yingying Zhang, Yuping Zhang, Xiaoxi Yang, Rajendiran Keerthiga, Chen Fu, Ailing Fu
Summary: The synthesized hemiprotonic compounds in this study have selective antitumor, antibacterial, and antifungal activities, possibly exerting antitumor effects by specific inhibition of transcription factor PLAGL2, and showing sensitivity to drug-resistant bacteria.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Faisal Hayat Nazir, Elena Camporesi, Gunnar Brinkmalm, Tammaryn Lashley, Christina E. Toomey, Hlin Kvartsberg, Henrik Zetterberg, Kaj Blennow, Bruno Becker
Summary: The study identified multiple molecular forms of neurogranin in cerebrospinal fluid, including monomeric full-length neurogranin, N- and C-terminal truncations, and larger forms of unknown composition.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Marie-Eva Pickering, Aicha Ltaief-Boudrigua, Elodie Feurer, Corinne Collet, Roland Chapurlat
Summary: Camurati-Engelmann disease is a rare autosomal dominant bone dysplasia associated with mutations in the TGF beta 1 gene. A young woman was hospitalized with severe pain in her lower limbs, accompanied by radiographic hyperostosis and sclerosis of the long bones. Research has found that a rare missense variant in the LRP6 gene is associated with radiographic features of Camurati-Engelmann disease. More studies are needed to further investigate the pathological role of this variant in Camurati-Engelmann-like disease.
Article
Biochemistry & Molecular Biology
Lingyun Wang, Guojin Wu, Ji-Bin Peng
Summary: A novel C-terminal motif in WNK4 that can mediate its degradation by KLHL3 was identified. In addition to the known acidic motif, there are other motifs in WNK4 that interact with KLHL3. This finding helps explain why PHAII is less severe when WNK4 is mutated compared to KLHL3.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Chemistry, Organic
David Szamosvari, Viktoriia Savchenko, Natalie Badouin, Thomas Boettcher
Summary: The Pseudomonas quinolone signal (PQS) plays a vital role in controlling the pathogenicity of Pseudomonas aeruginosa. PQS exhibits diverse biological functions, including iron trapping. In this study, we synthesized two types of crosslinked dimeric PQS motifs as potential iron chelators and successfully chelated ferric iron, forming colorful and fluorescent complexes with other metal ions. Furthermore, we explored the metal ion binding capabilities of natural PQS and identified additional metal complexes beyond ferric iron, confirming the complex stoichiometry using mass spectrometry.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Zhong Yao, Betty Geng, Edyta Marcon, Shuye Pu, Hua Tang, John Merluza, Alexander Bello, Jamie Snider, Ping Lu, Heidi Wood, Igor Stagljar
Summary: The spike (S) protein of the SARS-CoV-2 virus is responsible for binding to the ACE2 receptor and entering host cells. Reductive cleavage may occur due to the presence of multiple disulfide bonds in the S protein. In this study, the vulnerability of S proteins from different virus variants, especially the Omicron family, to reduction was evaluated using a luciferase-based binding assay. It was found that Omicron mutations in the receptor binding module (RBM) facilitate cleavage of certain disulfide bonds, impairing binding activity and protein stability. The vulnerability of Omicron S proteins suggests a potential mechanism for treating specific SARS-CoV-2 strains.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Chemistry, Medicinal
Luke A. Adams, Lorna E. Wilkinson-White, Menachem J. Gunzburg, Stephen J. Headey, Biswaranjan Mohanty, Martin J. Scanlon, Ben Capuano, Joel P. Mackay, Bradley C. Doak
Summary: A systematic workflow, called Rapid Elaboration of Fragments into Leads (REFiL), allows for the rapid improvement of binding affinity and evolution of low-affinity fragment hits into higher-affinity leads without the need for structural information.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jiangdong Huo, Audrey Le Bas, Reinis R. Ruza, Helen M. E. Duyvesteyn, Halina Mikolajek, Tomas Malinauskas, Tiong Kit Tan, Pramila Rijal, Maud Dumoux, Philip N. Ward, Jingshan Ren, Daming Zhou, Peter J. Harrison, Miriam Weckener, Daniel K. Clare, Vinod K. Vogirala, Julika Radecke, Lucile Moynie, Yuguang Zhao, Javier Gilbert-Jaramillo, Michael L. Knight, Julia A. Tree, Karen R. Buttigieg, Naomi Coombes, Michael J. Elmore, Miles W. Carroll, Loic Carrique, Pranav N. M. Shah, William James, Alain R. Townsend, David Stuart, Raymond J. Owens, James H. Naismith
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Kuan-Ying A. Huang, Daming Zhou, Elizabeth E. Fry, Abhay Kotecha, Peng-Nien Huang, Shu-Li Yang, Kuo-Chien Tsao, Yhu-Chering Huang, Tzou-Yien Lin, Jingshan Ren, David I. Stuart
NATURE COMMUNICATIONS
(2020)
Article
Microbiology
Melanie Chitray, Abhay Kotecha, Peninah Nsamba, Jingshan Ren, Sonja Maree, Tovhowani Ramulongo, Guntram Paul, Jacques Theron, Elizabeth E. Fry, David Stuart, Francois F. Maree
Article
Biology
Yuguang Zhao, Jingshan Ren, James Hillier, Weixian Lu, Edith Yvonne Jones
COMMUNICATIONS BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Piyada Supasa, Daming Zhou, Wanwisa Dejnirattisai, Chang Liu, Alexander J. Mentzer, Helen M. Ginn, Yuguang Zhao, Helen M. E. Duyvesteyn, Rungtiwa Nutalai, Aekkachai Tuekprakhon, Beibei Wang, Guido C. Paesen, Jose Slon-Campos, Cesar Lopez-Camacho, Bassam Hallis, Naomi Coombes, Kevin R. Bewley, Sue Charlton, Thomas S. Walter, Eleanor Barnes, Susanna J. Dunachie, Donal Skelly, Sheila F. Lumley, Natalie Baker, Imam Shaik, Holly E. Humphries, Kerry Godwin, Nick Gent, Alex Sienkiewicz, Christina Dold, Robert Levin, Tao Dong, Andrew J. Pollard, Julian C. Knight, Paul Klenerman, Derrick Crook, Teresa Lambe, Elizabeth Clutterbuck, Sagida Bibi, Amy Flaxman, Mustapha Bittaye, Sandra Belij-Rammerstorfer, Sarah Gilbert, David R. Hall, Mark A. Williams, Neil G. Paterson, William James, Miles W. Carroll, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David Stuart, Gavin R. Screaton
Summary: Research on the UK-dominant variant B.1.1.7 shows that it is harder to neutralize than the parental virus, but widespread escape from antibodies or monoclonal antibodies has not been observed yet.
Article
Biochemistry & Molecular Biology
Wanwisa Dejnirattisai, Daming Zhou, Helen M. Ginn, Helen M. E. Duyvesteyn, Piyada Supasa, James Brett Case, Yuguang Zhao, Thomas S. Walter, Alexander J. Mentzer, Chang Liu, Beibei Wang, Guido C. Paesen, Jose Slon-Campos, Cesar Lopez-Camacho, Natasha M. Kafai, Adam L. Bailey, Rita E. Chen, Baoling Ying, Craig Thompson, Jai Bolton, Alex Fyfe, Sunetra Gupta, Tiong Kit Tan, Javier Gilbert-Jaramillo, William James, Michael Knight, Miles W. Carroll, Donal Skelly, Christina Dold, Yanchun Peng, Robert Levin, Tao Dong, Andrew J. Pollard, Julian C. Knight, Paul Klenerman, Nigel Temperton, David R. Hall, Mark A. Williams, Neil G. Paterson, Felicity K. R. Bertram, C. Alistair Siebert, Daniel K. Clare, Andrew Howe, Julika Radecke, Yun Song, Alain R. Townsend, Kuan-Ying A. Huang, Elizabeth E. Fry, Juthathip Mongkolsapaya, Michael S. Diamond, Jingshan Ren, David Stuart, Gavin R. Screaton
Summary: Antibodies play a crucial role in immune protection against SARS-CoV-2, with some being used as therapeutics. A study identified 377 human monoclonal antibodies, focusing on 80 that bind the virus spike, and found that most highly inhibitory antibodies can block the virus-receptor interaction. Novel binding modes of potent inhibitory antibodies were discovered, showing potential for prophylactic or therapeutic use in animal models.
Article
Biochemistry & Molecular Biology
Daming Zhou, Wanwisa Dejnirattisai, Piyada Supasa, Chang Liu, Alexander J. Mentzer, Helen M. Ginn, Yuguang Zhao, Helen M. E. Duyvesteyn, Aekkachai Tuekprakhon, Rungtiwa Nutalai, Beibei Wang, Guido C. Paesen, Cesar Lopez-Camacho, Jose Slon-Campos, Bassam Hallis, Naomi Coombes, Kevin Bewley, Sue Charlton, Thomas S. Walter, Donal Skelly, Sheila F. Lumley, Christina Dold, Robert Levin, Tao Dong, Andrew J. Pollard, Julian C. Knight, Derrick Crook, Teresa Lambe, Elizabeth Clutterbuck, Sagida Bibi, Amy Flaxman, Mustapha Bittaye, Sandra Belij-Rammerstorfer, Sarah Gilbert, William James, Miles W. Carroll, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David Stuart, Gavin R. Screaton
Summary: The race to develop vaccines against SARS-CoV-2 variants, such as B.1.1.7, B.1.351, and P.1, is ongoing as these variants have mutations in the spike protein, potentially leading to immune escape. A structure-function analysis of B.1.351 revealed tighter ACE2 binding and widespread evasion from monoclonal antibody neutralization, particularly driven by the E484K mutation.
Article
Biochemistry & Molecular Biology
Wanwisa Dejnirattisai, Daming Zhou, Piyada Supasa, Chang Liu, Alexander J. Mentzer, Helen M. Ginn, Yuguang Zhao, Helen M. E. Duyvesteyn, Aekkachai Tuekprakhon, Rungtiwa Nutalai, Beibei Wang, Cesar Lopez-Camacho, Jose Slon-Campos, Thomas S. Walter, Donal Skelly, Sue Ann Costa Clemens, Felipe Gomes Naveca, Valdinete Nascimento, Fernanda Nascimento, Cristiano Fernandes da Costa, Paola Cristina Resende, Alex Pauvolid-Correa, Marilda M. Siqueira, Christina Dold, Robert Levin, Tao Dong, Andrew J. Pollard, Julian C. Knight, Derrick Crook, Teresa Lambe, Elizabeth Clutterbuck, Sagida Bibi, Amy Flaxman, Mustapha Bittaye, Sandra Belij-Rammerstorfer, Sarah C. Gilbert, Miles W. Carroll, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Neil G. Paterson, Mark A. Williams, David R. Hall, Ruben J. G. Hulswit, Thomas A. Bowden, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David Stuart, Gavin R. Screaton
Summary: Ending the SARS-CoV-2 pandemic requires global vaccination. New virus strains with mutations impact antibody responses, but some variants are less resistant than others. A monoclonal antibody can neutralize different variants and partially restore neutralization potency for other public antibodies.
Article
Biochemistry & Molecular Biology
Chang Liu, Helen M. Ginn, Wanwisa Dejnirattisai, Piyada Supasa, Beibei Wang, Aekkachai Tuekprakhon, Rungtiwa Nutalai, Daming Zhou, Alexander J. Mentzer, Yuguang Zhao, Helen M. E. Duyvesteyn, Cesar Lopez-Camacho, Jose Slon-Campos, Thomas S. Walter, Donal Skelly, Sile Ann Johnson, Thomas G. Ritter, Chris Mason, Sue Ann Costa Clemens, Felipe Gomes Naveca, Valdinete Nascimento, Fernanda Nascimento, Cristiano Fernandes da Costa, Paola Cristina Resende, Alex Pauvolid-Correa, Marilda M. Siqueira, Christina Dold, Nigel Temperton, Tao Dong, Andrew J. Pollard, Julian C. Knight, Derrick Crook, Teresa Lambe, Elizabeth Clutterbuck, Sagida Bibi, Amy Flaxman, Mustapha Bittaye, Sandra Belij-Rammerstorfer, Sarah C. Gilbert, Tariq Malik, Miles W. Carroll, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Vicky Baillie, Natali Serafin, Zanele Ditse, Kelly Da Silva, Neil G. Paterson, Mark A. Williams, David R. Hall, Shabir Madhi, Marta C. Nunes, Philip Goulder, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David Stuart, Gavin R. Screaton
Summary: Recent study examined the neutralizing ability of monoclonal antibodies, convalescent and vaccine sera against the Indian variants B.1.617.1 and B.1.617.2, showing that the neutralization of these variants is reduced compared to the ancestral strains, without widespread antibody escape as seen in other variants like B.1.351.
Article
Biochemistry & Molecular Biology
Wanwisa Dejnirattisai, Jiandong Huo, Daming Zhou, Jiri Zahradnik, Piyada Supasa, Chang Liu, Helen M. E. Duyvesteyn, Helen M. Ginn, Alexander J. Mentzer, Aekkachai Tuekprakhon, Rungtiwa Nutalai, Beibei Wang, Aiste Dijokaite, Suman Khan, Ori Avinoam, Mohammad Bahar, Donal Skelly, Sandra Adele, Sile Ann Johnson, Ali Amini, Thomas G. Ritter, Chris Mason, Christina Dold, Daniel Pan, Sara Assadi, Adam Bellass, Nicola Omo-Dare, David Koeckerling, Amy Flaxman, Daniel Jenkin, Parvinder K. Aley, Merryn Voysey, Sue Ann Costa Clemens, Felipe Gomes Naveca, Valdinete Nascimento, Fernanda Nascimento, Cristiano Fernandes da Costa, Paola Cristina Resende, Alex Pauvolid-Correa, Marilda M. Siqueira, Vicky Baillie, Natali Serafin, Gaurav Kwatra, Kelly Da Silva, Shabir A. Madhi, Marta C. Nunes, Tariq Malik, Peter J. M. Openshaw, J. Kenneth Baillie, Malcolm G. Semple, Alain R. Townsend, Kuan-Ying A. Huang, Tiong Kit Tan, Miles W. Carroll, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Bede Constantinides, Hermione Webster, Derrick Crook, Andrew J. Pollard, Teresa Lambe, Neil G. Paterson, Mark A. Williams, David R. Hall, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, Gideon Schreiber, David Stuart, Gavin R. Screaton
Summary: On November 24, 2021, the sequence of a new SARS-CoV-2 variant, Omicron-B.1.1.529, was announced. Compared to previous variants, Omicron has a higher number of mutations in the Spike (S) protein. Serum neutralization of Omicron by individuals vaccinated or previously infected with Alpha, Beta, Gamma, or Delta variants is significantly reduced or ineffective. Third vaccine doses can boost neutralization titers against Omicron, and high titers are observed in both vaccinated individuals and those infected with the Delta variant. Most potent monoclonal antibodies and antibodies under development are unable to effectively neutralize Omicron due to mutations in its Spike protein. Omicron has structural changes compared to earlier viruses and utilizes mutations that enhance its binding to ACE2, allowing for immune escape. This results in a large number of mutations in the ACE2 binding site and a rebalancing of receptor affinity similar to earlier pandemic viruses.
Article
Microbiology
Chang Liu, Daming Zhou, Rungtiwa Nutalai, Helen M. E. Duyvesteyn, Aekkachai Tuekprakhon, Helen M. Ginn, Wanwisa Dejnirattisai, Piyada Supasa, Alexander J. Mentzer, Beibei Wang, James Brett Case, Yuguang Zhao, Donal T. Skelly, Rita E. Chen, Sile Ann Johnson, Thomas G. Ritter, Chris Mason, Tariq Malik, Nigel Temperton, Neil G. Paterson, Mark A. Williams, David R. Hall, Daniel K. Clare, Andrew Howe, Philip J. R. Goulder, Elizabeth E. Fry, Michael S. Diamond, Juthathip Mongkolsapaya, Jingshan Ren, David Stuart, Gavin R. Screaton
Summary: This study investigated several variants of SARS-CoV-2 and found that the Beta variant has the largest antigenic difference compared to other variants, such as Delta, and is poorly neutralized by serum from early pandemic and Delta viruses. The study also revealed that certain antibodies can recognize conserved neutralizing epitopes, while others target specific mutated residues in the Beta variant.
CELL HOST & MICROBE
(2022)
Article
Medicine, Research & Experimental
Kuan-Ying A. Huang, Daming Zhou, Tiong Kit Tan, Charles Chen, Helen M. E. Duyvesteyn, Yuguang Zhao, Helen M. Ginn, Ling Qin, Pramila Rijal, Lisa Schimanski, Robert Donat, Adam Harding, Javier Gilbert-Jaramillo, William James, Julia A. Tree, Karen Buttigieg, Miles Carroll, Sue Charlton, Chia-En Lien, Meei-Yun Lin, Cheng-Pin Chen, Shu-Hsing Cheng, Xiaorui Chen, Tzou-Yien Lin, Elizabeth E. Fry, Jingshan Ren, Che Ma, Alain R. Townsend, David Stuart
Summary: The study reveals that representative antibodies targeting non-overlapping epitopes are effective against wild type virus and emerging variants. The neutralization is associated with the inhibition of viral RBD binding to ACE2. Structural analysis shows that these antibodies have unique features while sharing some similarities with previously reported neutralizing monoclonal antibodies.
Article
Biochemistry & Molecular Biology
Rungtiwa Nutalai, Daming Zhou, Aekkachai Tuekprakhon, Helen M. Ginn, Piyada Supasa, Chang Liu, Jiandong Huo, Alexander J. Mentzer, Helen M. E. Duyvesteyn, Aiste Dijokaite-Guraliuc, Donal Skelly, Thomas G. Ritter, Ali Amini, Sagida Bibi, Sandra Adele, Sile Ann Johnson, Bede Constantinides, Hermione Webster, Nigel Temperton, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Derrick Crook, Andrew J. Pollard, Teresa Lambe, Philip Goulder, Neil G. Paterson, Mark A. Williams, David R. Hall, Juthathip Mongkolsapaya, Elizabeth E. Fry, Wanwisa Dejnirattisai, Jingshan Ren, David Stuart, Gavin R. Screaton
Summary: This study compares the neutralization of Omicron variants of SARS-CoV-2 and finds that differences in neutralization mostly arise from variations in residues bordering the ACE2 binding site. Analysis of monoclonal antibodies isolated from vaccinated individuals shows that they can effectively neutralize early pandemic strains and exhibit broad reactivity with variants.
Article
Biochemistry & Molecular Biology
Aekkachai Tuekprakhon, Rungtiwa Nutalai, Aiste Dijokaite-Guraliuc, Daming Zhou, Helen M. Ginn, Muneeswaran Selvaraj, Chang Liu, Alexander J. Mentzer, Piyada Supasa, Helen M. E. Duyvesteyn, Raksha Das, Donal Skelly, Thomas G. Ritter, Ali Amini, Sagida Bibi, Sandra Adele, Sile Ann Johnson, Bede Constantinides, Hermione Webster, Nigel Temperton, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Derrick Crook, Andrew J. Pollard, Teresa Lambe, Philip Goulder, Neil G. Paterson, Mark A. Williams, David R. Hall, Elizabeth E. Fry, Jiandong Huo, Juthathip Mongkolsapaya, Jingshan Ren, David Stuart, Gavin R. Screaton
Summary: The Omicron variant of SARS-CoV-2 has rapidly spread globally and has evolved into different sublineages, with BA.4 and BA.5 dominating in South Africa. These sublineages show reduced neutralization by vaccine and naturally immune serum, indicating the possibility of repeat Omicron infections.
Article
Biology
Ronggang Song, Jing Ren, Junxia Sun, Ming Li
Summary: The combination of melatonin postconditioning and sitagliptin pretreatment significantly reduces myocardial ischemia-reperfusion injury in diabetic aged rats by modulating oxidative stress, apoptosis, and the AMPK/SIRT1 pathway, showcasing a potential central mechanism for cardioprotection.
ARCHIVES OF BIOLOGICAL SCIENCES
(2021)
