The role of RNA modifications in the regulation of tRNA cleavage

Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells

(2018) Nicola Guzzi et al.   CELL

Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs

(2018) Yunfang Zhang et al.   NATURE CELL BIOLOGY

Drosophila tsRNAs preferentially suppress general translation machinery via antisense pairing and participate in cellular starvation response

(2018) Shiqi Luo et al.   NUCLEIC ACIDS RESEARCH

Mutations in Cytosine-5 tRNA Methyltransferases Impact Mobile Element Expression and Genome Stability at Specific DNA Repeats

(2018) Bianca Genenncher et al.   Cell Reports

Identification of two novel functional tRNA-derived fragments induced in response to respiratory syncytial virus infection

(2017) Jiehua Zhou et al.   JOURNAL OF GENERAL VIROLOGY

RNA G-Quadruplexes in Biology: Principles and Molecular Mechanisms

(2017) Marta M. Fay et al.   JOURNAL OF MOLECULAR BIOLOGY

MODOMICS: a database of RNA modification pathways. 2017 update

(2017) Pietro Boccaletto et al.   NUCLEIC ACIDS RESEARCH

tRNA-derived small RNAs target transposable element transcripts

(2017) German Martinez et al.   NUCLEIC ACIDS RESEARCH

Pre-mRNA processing includes N 6 methylation of adenosine residues that are retained in mRNA exons and the fallacy of “RNA epigenetics”

(2017) Robert B. Darnell et al.   RNA

Rapid RNase L–driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery

(2017) Jesse Donovan et al.   RNA

Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs

(2017) Shawn M. Lyons et al.   Nature Communications

Understanding RNA modifications: the promises and technological bottlenecks of the ‘epitranscriptome’

(2017) Matthias Schaefer et al.   Open Biology

Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and Motility

(2017) Joana V. Flores et al.   Stem Cell Reports

Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells

(2016) Kevin A. Goncalves et al.   CELL

Mechanistic insights into mammalian stress granule dynamics

(2016) Marc D. Panas et al.   JOURNAL OF CELL BIOLOGY

Stem cell function and stress response are controlled by protein synthesis

(2016) Sandra Blanco et al.   NATURE

The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA

(2016) Dan Dominissini et al.   NATURE

Selective amplification and sequencing of cyclic phosphate–containing RNAs by the cP-RNA-seq method

(2016) Shozo Honda et al.   Nature Protocols

YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression

(2016) Shawn M. Lyons et al.   NUCLEIC ACIDS RESEARCH

A tRNA-derived fragment competes with mRNA for ribosome binding and regulates translation during stress

(2016) Jennifer Gebetsberger et al.   RNA Biology

RNA biology of angiogenin: Current state and perspectives

(2016) Shawn M. Lyons et al.   RNA Biology

RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria

(2016) J. U. Guo et al.   SCIENCE

Three decades of research on angiogenin: a review and perspective

(2015) Jinghao Sheng et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Respiratory Syncytial Virus Utilizes a tRNA Fragment to Suppress Antiviral Responses Through a Novel Targeting Mechanism

(2015) Junfang Deng et al.   MOLECULAR THERAPY

GtRNAdb 2.0: an expanded database of transfer RNA genes identified in complete and draft genomes

(2015) Patricia P. Chan et al.   NUCLEIC ACIDS RESEARCH

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

Loss of Anticodon Wobble Uridine Modifications Affects tRNALys Function and Protein Levels in Saccharomyces cerevisiae

(2015) Roland Klassen et al.   PLoS One

Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets

(2014) Pankaj Kumar et al.   BMC BIOLOGY

Human CLP1 Mutations Alter tRNA Biogenesis, Affecting Both Peripheral and Central Nervous System Function

(2014) Ender Karaca et al.   CELL

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

(2014) S. Blanco et al.   EMBO JOURNAL

tRNA modifications regulate translation during cellular stress

(2014) Chen Gu et al.   FEBS LETTERS

Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress

(2014) M. Saikia et al.   MOLECULAR AND CELLULAR BIOLOGY

Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells

(2014) Thomas M. Carlile et al.   NATURE

Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors

(2014) Johannes Popow et al.   NATURE

Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry

(2014) Dan Su et al.   Nature Protocols

A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation

(2014) Kevin K. Desai et al.   NUCLEIC ACIDS RESEARCH

G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments

(2014) Pavel Ivanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration

(2014) R. Ishimura et al.   SCIENCE

5′ tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction

(2013) Joseph M Dhahbi et al.   BMC GENOMICS

Unusual Noncanonical Intron Editing Is Important for tRNA Splicing in Trypanosoma brucei

(2013) Mary Anne T. Rubio et al.   MOLECULAR CELL

CLP1 links tRNA metabolism to progressive motor-neuron loss

(2013) Toshikatsu Hanada et al.   NATURE

Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells

(2013) Andrew Sobala et al.   RNA Biology

Mutation in NSUN2, which Encodes an RNA Methyltransferase, Causes Autosomal-Recessive Intellectual Disability

(2012) Muzammil Ahmad Khan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in NSUN2 Cause Autosomal- Recessive Intellectual Disability

(2012) Lia Abbasi-Moheb et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response

(2012) Ashish Patil et al.   CELL CYCLE

Genome-wide Identification and Quantitative Analysis of Cleaved tRNA Fragments Induced by Cellular Stress

(2012) Mridusmita Saikia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Whole exome sequencing identifies a splicing mutation inNSUN2as a cause of a Dubowitz-like syndrome

(2012) Fernando Jose Martinez et al.   JOURNAL OF MEDICAL GENETICS

Identification and Functional Characterization of tRNA-derived RNA Fragments (tRFs) in Respiratory Syncytial Virus Infection

(2012) Qingrong Wang et al.   MOLECULAR THERAPY

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis

(2012) Francesca Tuorto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs

(2012) Zhihua Li et al.   NUCLEIC ACIDS RESEARCH

Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications

(2012) Ashish Patil et al.   RNA Biology

Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins

(2012) Clement T.Y. Chan et al.   Nature Communications

tRNA-Derived Fragments Target the Ribosome and Function as Regulatory Non-Coding RNA inHaloferax volcanii

(2012) Jennifer Gebetsberger et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation

(2011) Pavel Ivanov et al.   MOLECULAR CELL

HSPC117 Is the Essential Subunit of a Human tRNA Splicing Ligase Complex

(2011) J. Popow et al.   SCIENCE

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

(2010) M. Schaefer et al.   GENES & DEVELOPMENT

Angiogenin-induced tRNA-derived Stress-induced RNAs Promote Stress-induced Stress Granule Assembly

(2010) Mohamed M. Emara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Capture and sequence analysis of RNAs with terminal 2',3'-cyclic phosphates

(2010) K. Schutz et al.   RNA

Human tRNA-derived small RNAs in the global regulation of RNA silencing

(2010) D. Haussecker et al.   RNA

T2 Family ribonucleases: ancient enzymes with diverse roles

(2010) Natalie Luhtala et al.   TRENDS IN BIOCHEMICAL SCIENCES

A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)

(2009) Yong Sun Lee et al.   GENES & DEVELOPMENT

The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress inSaccharomyces cerevisiae

(2009) Debrah M. Thompson et al.   JOURNAL OF CELL BIOLOGY

Angiogenin cleaves tRNA and promotes stress-induced translational repression

(2009) Satoshi Yamasaki et al.   JOURNAL OF CELL BIOLOGY

Functional Analysis of Human tRNA Isodecoders

(2009) Renaud Geslain et al.   JOURNAL OF MOLECULAR BIOLOGY

The Phloem-Delivered RNA Pool Contains Small Noncoding RNAs and Interferes with Translation

(2009) S. Zhang et al.   PLANT PHYSIOLOGY

Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs

(2009) C. Cole et al.   RNA

Stress induces tRNA cleavage by angiogenin in mammalian cells

(2008) Hanjiang Fu et al.   FEBS LETTERS

Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1

(2008) I. Chernyakov et al.   GENES & DEVELOPMENT

tRNA cleavage is a conserved response to oxidative stress in eukaryotes

(2008) D. M. Thompson et al.   RNA