期刊
FEBS LETTERS
卷 588, 期 22, 页码 4176-4181出版社
WILEY
DOI: 10.1016/j.febslet.2014.03.034
关键词
Innate lymphoid cells; Mucosal immunity; ROR gamma t; IL-22
资金
- Agence Nationale de la Recherche
- Fond de la Recherche Medicale
- Institut Pasteur and a Marie Curie intra-European fellowship
ROR gamma t(+) innate lymphoid cells (ILCs), or ILC3, play a fundamental role in the development of lymphoid tissues, as well as in homeostasis and defence of mucosal tissues. These cells produce IL-22, IL-17A and LT alpha 1 beta 2, key cytokines for the activation of epithelial defences and the recruitment of polymorphonuclear phagocytes. In the absence of ILC3, the early defence to infection and resistance to injury are compromised. Given the importance of ILC3 in mucosal immunity, significant efforts are made to discover their multiple functions and decipher their mode of action and regulation. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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