期刊
FEBS LETTERS
卷 588, 期 22, 页码 4182-4187出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2014.03.018
关键词
Regulatory T cell; Commensal microbe; Dietary factor
资金
- Ministry of Education, Culture, Sports, Science, and Technology
- Ministry of Health, Labour and Welfare
- Osaka Foundation for the Promotion of Clinical Immunology
To maintain a quiescent gut microenvironment, proper regulation of immune responses initiated by pro-inflammatory immune subsets is required. Several types of regulatory T cells are reported to exert pivotal roles in achieving this. Among various types of regulatory T cells, the crucial role of Foxp(3+) Treg cells has been well documented. Furthermore, accumulating evidence demonstrates that both microbial and dietary factors influence the induction and suppressor functions of intestinal Foxp(3+) Treg cells. Foxp(3+) Treg cells are a highly activated T cell subset which responds rapidly to environmental and nutritional stimuli. Thus, sufficient nutrient supply is required to fuel the high energetic status of Foxp(3+) Treg cells for the regulation of intestinal immunity. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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