期刊
FEBS LETTERS
卷 588, 期 16, 页码 2610-2615出版社
WILEY
DOI: 10.1016/j.febslet.2014.03.054
关键词
Mutant p53; microRNA; miRNA; Let-7; miR-130b; miR-128-2; miR-155; miR-223; miR-27a; miR-205; Gain-of-function; Invasion; Metastasis; Cancer
资金
- Intramural NIH HHS [ZIA BC011399-01] Funding Source: Medline
MicroRNAs are potent regulators of gene expression and modulate multiple cellular processes including proliferation, differentiation and apoptosis. A number of microRNAs have been shown to be regulated by p53, the most frequently mutated gene in human cancer. It is has been demonstrated that some mutant p53 proteins not only lose tumor suppressor activity, but also acquire novel oncogenic functions that are independent of wild-type p53. In this review, we highlight recent evidences suggesting that some mutant p53 proteins regulate the expression of specific microRNAs to gain oncogenic functions and identify a gene network regulated by the microRNAs downstream of mutant p53. (C) 2014 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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