期刊
FEBS LETTERS
卷 588, 期 22, 页码 4102-4111出版社
WILEY
DOI: 10.1016/j.febslet.2014.02.052
关键词
Intestine; Epithelium; Immune system; Mucosal immunology; Microbial ecology; Inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Pattern recognition receptor; Innate lymphoid cell; Microbiome
资金
- NCI NIH HHS [P30 CA016042] Funding Source: Medline
- NIAID NIH HHS [R01 AI078885] Funding Source: Medline
- NIDCR NIH HHS [U54 DE023798] Funding Source: Medline
- NIDDK NIH HHS [R01 DK085691, P01 DK046763, U01 DK062413] Funding Source: Medline
The mucosal immune system - consisting of adaptive and innate immune cells as well as the epithelium - is profoundly influenced by its microbial environment. There is now growing evidence that the converse is also true, that the immune system shapes the composition of the intestinal microbiome. During conditions of health, this bidirectional interaction achieves a homeostasis in which inappropriate immune responses to non-pathogenic microbes are averted and immune activity suppresses blooms of potentially pathogenic microbes (pathobionts). Genetic alteration in immune/epithelial function can affect host gardening of the intestinal microbiome, contributing to the diversity of intestinal microbiota within a population and in some cases allowing for unfavorable microbial ecologies (dysbiosis) that confer disease susceptibility. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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