Article
Pharmacology & Pharmacy
Minghui Wang, Jingyan Li, Yanqing Ding, Sidong Cai, Zhuoming Li, Peiqing Liu
Summary: PEX5 protects cardiomyocytes against hypertrophy by regulating redox homeostasis and inhibiting redox-sensitive signaling pathways MAPK and STAT3.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ravi Sonkar, Ryan Berry, Mary N. Latimer, Sumanth D. Prabhu, Martin E. Young, Stuart J. Frank
Summary: Circadian clocks regulate various biological processes, including hormone secretion and target tissue sensitivity. This study found that genetic disruption of the cardiomyocyte circadian clock leads to cardiomyopathy, potentially due to excessive activation of cardiac GH/IGF1 signaling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Bohui Peng, Chang Peng, Xiaomei Luo, Shuqi Wu, Qian Mao, Huanting Zhang, Xiao Han
Summary: This study revealed the role of the JNK/MAPK signaling pathway in phenylephrine-induced cardiac hypertrophy, demonstrating that both JNK and HAT inhibitors can attenuate cardiomyocyte hypertrophy and dysfunction by inhibiting P300 and PCAF. These findings provide a new research direction for the prevention and treatment of cardiac hypertrophy.
Article
Cardiac & Cardiovascular Systems
Yu Fang, Shun Wang, Jian Lv, Zhenyi Zhao, Ningning Guo, Gang Wu, Jingjing Tong, Zhihua Wang
Summary: Zinc dyshomeostasis is involved in cardiac hypertrophy, with Slc39a2 playing a key role in regulating zinc uptake and hypertrophic responses. The study also suggests that innate immune signaling pathways are affected by Slc39a2 deficiency, influencing the hypertrophic state of cardiomyocytes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Lin Hu, Ziyuan Wang, Huan Li, Jiarui Wei, Fengyue Tang, Qing Wang, Jing Wang, Xiaoqiao Zhang, Qiufang Zhang
Summary: The study found that Icariin, a compound derived from Epimedium, can alleviate ISO-induced cardiomyocyte hypertrophy and protect the cells by enhancing autophagy and reducing apoptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Cell Biology
Megan Rowton, Alexander Guzzetta, Ariel B. Rydeen, Ivan P. Moskowitz
Summary: Congenital Heart Disease (CHD), malformations of the heart at birth, is the most common life-threatening birth defect. The research challenge lies in elucidating the genetic determinants of CHD and linking CHD ontogeny to a molecular understanding of heart development. Tight temporal control of progenitor differentiation is crucial for normal organ size, spatial organization, and cellular physiology.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Mayarling Francisca Troncoso, Mario Pavez, Carlos Wilson, Daniel Lagos, Javier Duran, Sebastian Ramos, Genaro Barrientos, Patricio Silva, Paola Llanos, Carla Basualto-Alarcon, B. Daan Westenbrink, Sergio Lavandero, Manuel Estrada
Summary: Testosterone stimulates glucose metabolism in cardiomyocytes by activating AMPK and AR signaling, leading to cardiomyocyte hypertrophy.
BIOLOGICAL RESEARCH
(2021)
Article
Orthopedics
S. Monteagudo, F. M. F. Cornelis, X. Wang, A. de Roover, T. Peeters, J. Quintiens, A. Sermon, R. C. de Almeida, I Meulenbelt, R. J. Lories
Summary: ANP32A is identified as a novel repressor of Wnt signaling in articular cartilage, and its loss leads to hyper-activation of Wnt signaling. ANP32A inhibits target gene expression by histone acetylation masking. The study also reveals the involvement of ANP32A in cardiac hypertrophy. These findings have significant implications for understanding the pathogenesis of osteoarthritis and cardiac diseases.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Developmental Biology
Alberto Bertozzi, Chi-Chung Wu, Stefan Hans, Michael Brand, Gilbert Weidinger
Summary: The Wnt/β-catenin signaling pathway is shown to play a positive role in heart regeneration in zebrafish, promoting cardiomyocyte proliferation, dedifferentiation, and scar maturation. Contrary to previous reports, this new study supports the importance of Wnt/β-catenin signaling in the regeneration process.
DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Xiangwen Peng, Kaa Seng Lai, Peilu She, Junsu Kang, Tingting Wang, Guobao Li, Yating Zhou, Jianjian Sun, Daqing Jin, Xiaolei Xu, Lujian Liao, Jiandong Liu, Ethan Lee, Kenneth D. Poss, Tao P. Zhong
Summary: The study found that after cardiac injury in zebrafish, the expression of secreted Wnt inhibitors is induced in the cardiac tissue, blocking Wnt signaling pathway can promote cardiomyocyte proliferation and heart regeneration, whereas activation of Wnt8 signaling pathway inhibits injury-induced cardiomyocyte dedifferentiation and proliferation.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Xuan Wang, Tianwei He, Lei He, Bu Yang, Zhongyu Liu, Mao Pang, Peigen Xie, Liangming Zhang, Limin Rong
Summary: The study demonstrates that melatonin enhances the hypertrophic differentiation of MSC-derived chondrocytes through the Wnt signaling pathway, increasing chondrocyte cell volume and type X collagen expression while decreasing type II collagen expression.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biology
Nor Hidayah Mustafa, Juriyati Jalil, Mohammed S. M. Saleh, Satirah Zainalabidin, Ahmad Yusof Asmadi, Yusof Kamisah
Summary: Cardiac hypertrophy is an early hallmark of heart failure, and therapeutic strategies targeting the MAPK/NFAT signaling pathway may help prevent cardiac dysfunction. The study investigated the effects of various fractions of Parkia speciosa Hassk ethanol extract on angiotensin II-induced cardiomyocyte hypertrophy. The ethyl acetate (EA) fraction demonstrated the most potent antihypertrophic effect and attenuated the activation of the MAPK/calcineurin-NFAT signaling pathway.
Article
Biochemistry & Molecular Biology
Manuel Schmidt, Christine Poser, Christina Janster, Julia von Maltzahn
Summary: The hairpin region of WNT7A in its C-terminus is fully sufficient to induce non-canonical signaling in myogenic cells, leading to hypertrophy, expansion of satellite stem cells, and migration of myoblasts. The linker region in the C-terminus of WNT7A binds to the FZD7 receptor but does not activate non-canonical Wnt signaling. The hairpin and linker regions of WNT7A can independently activate canonical Wnt signaling.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Jun Luo, Stephen D. D. Farris, Deri Helterline, April Stempien-Otero
Summary: Cardiomyocytes increase DNA content in response to stress in humans, but this study found that DNA content decreases in unloaded hearts. Changes in DNA content were independent of cell proliferation. The study used a novel imaging flow cytometry methodology to compare human subjects with LVAD implantation or primary transplantation. Results showed that cardiomyocyte size decreased and DNA content per nucleus significantly decreased in unloaded hearts, while cell-cycle markers were not increased.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Physiology
Sunil Yeruva, Lars Koerber, Matthias Hiermaier, Desalegn T. Egu, Ellen Kempf, Jens Waschke
Summary: This study found that cholinergic signaling interacts with adrenergic signaling to regulate cardiomyocyte cohesion, with cholinergic signaling inhibiting the positive effect of adrenergic signaling.
