被撤回的出版物: MicroRNA-520g induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by targeting SMAD7 (vol 589, pg 102, 2015) (Retracted article. See vol. 596, pg. 526, 2022)

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Aberrant expression of miRNAs contributes to HCC development. Here, we observed elevated miR-520g expression in tumor samples from HCC patients with relapse and metastasis, and this high miR-520g expression was correlated with poor survival. Through gain-and loss-of-function studies, miR-520g was demonstrated to facilitate HCC cell migration, invasion and epithelial-mesenchymal transition (EMT). SMAD7 was identified as a direct target of miR-520g. Accordingly, we conclude that high miR-520g expression promotes HCC cell mobility and EMT by targeting SMAD7, and this is correlated with reduced survival in HCC patients. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Automated summary

The aberrant expression of miR-520g is correlated with relapse, metastasis, and poor survival in hepatocellular carcinoma patients. It promotes HCC cell migration, invasion, and epithelial-mesenchymal transition (EMT) by targeting SMAD7.