期刊
FEBS LETTERS
卷 588, 期 17, 页码 3104-3110出版社
WILEY
DOI: 10.1016/j.febslet.2014.06.045
关键词
Food-restriction; Clock genes; Peroxisome proliferator-activated receptor alpha; Nicotinamide phosphoribosyl transferase; Sirt1; Inhibitor of DNA binding 2
资金
- PAPiiT [IG200314]
- Consejo Nacional de Ciencia y Tecnologia (CONACyT), Mexico
Hepatic circadian transcription, considered to be driven by the liver clock, is largely influenced by food even uncoupling it from the suprachiasmatic nucleus (SCN). In SCN lesioned rats (SCNx) we determined the influence of a physiological feeding schedule on the entrainment of clock and clock-controlled (CCG) genes in the liver. We show that clock genes and the CCG Rev-erb alpha and peroxisome proliferator-activated receptor alpha (PPAR alpha) in food-scheduled intact and SCNx have a robust diurnal differential expression persisting after a 24 h fast. However, hepatic nicotinamide phosphoribosyl transferase (Nampt) shows time dependent changes that are lost in intact animals under fasting; moreover, it is unresponsive to the nutrient status in SCNx, indicating a poor reliance on liver clock genes and highlighting the relevance of SCN-derived signals for its metabolic status-related expression. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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