期刊
FEBS LETTERS
卷 588, 期 5, 页码 713-719出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2014.01.014
关键词
BKCa channel; Palmitoylation; Lateral diffusion; Quantum dot; Single molecule; Lipid raft
资金
- Science Research Center of Excellence Program of Korea Ministry of Science, ICT& Future Planning (MSIP)/National Research Foundation of Korea (NRF) [2007-0056157]
- [2011-0028665]
BKCa channels are palmitoylated at a cluster of cysteine residues within the cytosolic linker connecting the 1st and 2nd transmembrane domains, and this lipid modification affects their surface expression. To verify the effects of palmitoylation on the diffusional dynamics of BKCa channels, we investigated their lateral movement. Compared to wild-type channels, the movement of mutant palmitoylation-deficient channels was much less confined and close to random. The diffusion of the mutant channel was also much faster than that of the wild type. Thus, the lateral movement of BKCa channels is greatly influenced by palmitoylation. (c) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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