期刊
FEBS LETTERS
卷 588, 期 7, 页码 1136-1143出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2014.02.036
关键词
Proneural Gene; Neuroblast; Asymmetric cell division; Cell migration; C. elegans
资金
- National Basic Research Program of China (973 Program) [2013CB945600, 2012CB966800, 2012CB945002]
- National Natural Science Foundation of China [31222035, 31101002, 31171295, 31190063]
- Tsinghua University
- Junior Thousand Talents Program of China
Proneural genes control the generation of neuroblasts from the neuroepithelium, but their functions in neuroblast asymmetric division and migration remain elusive. Here, we identified Caenorhabditis elegans mutants of a proneural transcription factor (TF) lin-32, in which Q neuroblasts are produced. We showed that LIN-32 functions in parallel with a storkhead TF, HAM-1, to regulate Q neuroblast asymmetric division, and that Q neuroblast migration is inhibited in lin-32 alleles. Consistently, lin-32 is expressed throughout Q neuroblast lineage, suggesting that LIN-32 may promote different target gene expression. Our studies thus uncovered previously unknown functions of a proneural gene in neuroblast development. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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