期刊
FEBS LETTERS
卷 588, 期 7, 页码 1144-1153出版社
WILEY
DOI: 10.1016/j.febslet.2014.02.042
关键词
Methylglyoxal; Glutathione; Alcohol dehydrogenase 1; G2-phase arrest; Candida albicans
资金
- Research Fellowship of the BK21 project
We purified a fraction that showed NAD(+)-linked methylglyoxal dehydrogenase activity, directly catalyzing methylglyoxal oxidation to pyruvate, which was significantly increased in glutathione-depleted Candida albicans. It also showed NADH-linked methylglyoxal-reducing activity. The fraction was identified as a NAD(+)-linked alcohol dehydrogenase (ADH1) through mass spectrometric analyses. In ADH1-disruptants of both the wild type and glutathione-depleted cells, the intracellular methylglyoxal concentration increased significantly; defects in growth, differentiation, and virulence were observed; and G2-phase arrest was induced. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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