Article
Pharmacology & Pharmacy
Yen-Chang Chen, Jia-Hong Chen, Cheng-Fang Tsai, Chen-Teng Wu, Miao-Hsiang Wu, Pei-Chun Chang, Wei-Lan Yeh
Summary: The study found that nicardipine can inhibit the migration and colony formation of breast cancer cells, and increase the expression of Nrf2 and HO-1. The reduction of matrix metalloproteinase-9 by nicardipine is regulated by Nrf2/HO-1 axis and its catalytic end products.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sanu K. Shaji, G. Drishya, Damu Sunilkumar, Nanjan Pandurangan, Geetha B. Kumar, Bipin G. Nair
Summary: Less-studied flavonoid Tamarixetin demonstrated significant dose-dependent inhibition of MMP-9 expression and cancer cell migration and invasion potential, indicating its potential as an anti-cancer agent. The compound also inhibits crucial functions necessary for MMP-9 activation and modulates endogenous regulators of MMP-9 activity, suggesting it could be a template for novel therapeutic applications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ya-Tang Chiang, Yu-Bai Xiao, Shan-hui Hsu, Shu-Wei Chang, Chia-Ching Chou
Summary: Tannic acid (TA) has antibacterial, antioxidant, and anti-inflammatory properties and acts as an adhesive, hemostatic, and crosslinking agent in hydrogels. TA has been reported to inhibit MMP-2/- 9 activities, thereby improving tissue remodeling and wound healing. In this study, atomistic modeling was used to explore the mechanisms and structures of TA binding with MMP-2 and MMP-9, revealing the specific binding regions and molecular interactions involved. Understanding the binding mechanism and dynamics of TA with these MMPs provides crucial knowledge on the effects of TA on MMPs.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Chemistry, Analytical
Xintong Lu, Luoyu Ding, Haohan Song, Wenxin Yu, Chaoqing Dong, Jicun Ren
Summary: A novel in situ single molecule spectroscopy method based on fluorescent correlation spectroscopy (FCS) technique was proposed for measuring MMP-9 activity in single living cells. The method utilizes a fluorescent specific peptide and a reference dye as dual probes, and ratiometric translational diffusion time as the measurement parameter.
Review
Biochemistry & Molecular Biology
Shinji Takai, Denan Jin
Summary: Chymase-activated MMP-9 is closely related to the pathogenesis of various diseases, especially inflammation-related diseases. Upregulated chymase and MMP-9 have been observed in tissues from patients and animal models of these diseases. Chymase inhibitors attenuate MMP-9 formation and reduce inflammatory cell numbers, thereby ameliorating the development and progression of these disorders.
Article
Multidisciplinary Sciences
Yumi Kwon, Seong-Jun Park, Binh Thanh Nguyen, Mi Jeong Kim, Sejin Oh, Hwanho Lee, Narae Park, Hyun Seok Kim, Min-Jung Kang, Byung Soh Min, Jin-Won Lee, Eun Gyeong Yang, Cheolju Lee
Summary: The research analyzed plasma proteome of CRC patients, cancer secretome upon MMP-2 knockdown, and publicly available CRC tissue proteome data to unveil the perturbed proteomic signal during MMP-2 induced cancer progression. The integrative analysis revealed that EMT-associated proteins were regulated by MMP-2 perturbation and exhibited significantly increased expressions as disease progressed from TNM stage I to II. The study also identified a possible association between MMP-2 up-regulation and activation of focal adhesion kinase signaling in CRC patient tissues.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Fateme Eidizade, Mohammad Soukhtanloo, Rahele Zhiani, Jamshid Mehrzad, Farshad Mirzavi
Summary: This research investigates the effects of urolithin-B on glioblastoma multiforme (GBM) U87 cells. The results suggest that urolithin-B can decrease cell viability, induce necrosis and cell cycle arrest, increase reactive oxygen species production, and reduce cell migration in U87 cells. These findings indicate that urolithin-B may be a promising compound for GBM treatment.
Review
Biochemistry & Molecular Biology
Zainab Ahmed Rashid, Sanaa K. Bardaweel
Summary: Matrix metalloproteinases (MMPs), especially MMP-9, play a significant role in cancer pathogenesis and progression. However, no effective MMP-9 inhibitor has been approved by the FDA. This review focuses on exploring the strategies for designing MMP-9 inhibitors and their anticancer effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Ionut Luchian, Mihaela Moscalu, Ancuta Goriuc, Ludovica Nucci, Monica Tatarciuc, Ioana Martu, Mihai Covasa
Summary: Periodontitis results in destructive effects on periodontium, with increased levels of MMP-9. Periodontal treatment alone or combined with orthodontic treatment can improve clinical parameters and lower MMP-9 levels. The degree of malocclusion affects the treatment's impact on MMP-9 levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Chemistry, Medicinal
Sanjib Das, Sk Abdul Amin, Tarun Jha
Summary: Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) play significant roles in solid tumor invasion, metastasis, and angiogenesis, while their role in hematological malignancies is less understood. Recent studies have shown correlations between gelatinases and hematological malignancies, leading to the development of potential inhibitors for these conditions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Matthew Thomas Ferreira, Juliano Andreoli Miyake, Renata Nascimento Gomes, Fabio Feitoza, Pollyana Bulgarelli Stevannato, Andrew Silva da Cunha, Fernanda de Oliveira Serachi, Alexandros Theodoros Panagopoulos, Alison Colquhoun
Summary: The study demonstrated the importance of PGE(2) signaling through the EP2 and EP4 receptors in controlling GBM cell biology, as well as a relationship between COX1 and MMP2 in these cells. These findings suggest a potential novel therapeutic target for drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Panjian Lu, Gang Wang, Xiaoheng Lu, Pingping Qiao, Yifei Jin, Jun Yu, Qi Chen, Hongkui Wang
Summary: Matrix metalloproteinase 9 (MMP9) is an important gene up-regulated during peripheral nerve regeneration, and it plays a significant role in Schwann cell migration and phenotype modulation. The direct application of MMP9 recombinant protein enhances the regeneration process in injured rats by promoting Schwann cell migration, blood vessel formation, axon elongation, and myelin wrapping. MMP9 regulates both the extracellular and intracellular metabolism of Schwann cells.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yihe Wang, Christine Y. Chuang, Clare L. Hawkins, Michael J. Davies
Summary: Matrix metalloproteinase-9 (MMP9) plays a crucial role in the degradation of extracellular matrix (ECM) proteins. This study demonstrates that MMP9 can be activated by both chloramines and oxidation. The activation of MMP9 and ECM degradation are interdependent processes that may contribute to the progression of diseases.
Article
Pharmacology & Pharmacy
Hui Xin Wong, Chin Chiat Lee, Paul Chi-Lui Ho
Summary: This study compared the relevance of different wound healing models in keratinocytes and fibroblasts interaction physiologically. The conditioned media and transwell co-cultures models were found to be more suitable than co-cultures for wound healing research, as they better simulate layered tissue constructs and paracrine interactions in the physiological environment.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Oncology
Panpan Yin, Ying Su, Suhong Chen, Jinlin Wen, Feng Gao, Yanlin Wu, Xinyan Zhang
Summary: Oral squamous cell carcinoma (OSCC) is a common cancer in developing countries, with high mortality due to early metastasis. MMP-9 plays a key role in tumor invasion and metastasis. Knockdown of MMP-9 can suppress OSCC cell migration, proliferation, interactions with endothelial cells, tumor growth, and metastasis, potentially mediated through RhoC and Src gene expression.
ANALYTICAL CELLULAR PATHOLOGY
(2021)
