期刊
FEBS LETTERS
卷 588, 期 10, 页码 1869-1872出版社
WILEY
DOI: 10.1016/j.febslet.2014.04.002
关键词
Biofilm; Staphylococci; Exo-polysaccharide secretion; PNAG modification; O-succinylation
资金
- British Heart Foundation Senior Basic Science Research Fellowship [FS/12/36/29588]
- BBSRC
- Centre for Chronic Diseases and Disorders [C2D2]
- Institutional Strategic Support Fund (ISSF) award from the Wellcome Trust [097829/Z/11/A]
- British Heart Foundation [FS/09/023/27460, FS/12/36/29588] Funding Source: researchfish
Staphylococcus aureus and Staphylococcus epidermidis cause dangerous and difficult to treat medical device-related infections through their ability to form biofilms. Extracellular poly-N-acetylglucosamine (PNAG) facilitates biofilm formation and is a vaccination target, yet details of its biosynthesis by the icaADBC gene products is limited. IcaC is the proposed transporter for PNAG export, however a comparison of the Ica proteins to homologous exo-polysaccharide synthases suggests that the common IcaAD protein components both synthesise and transport the PNAG. The limited distribution of icaC to the Staphylococcaceae and its membership of a family of membrane-bound acyltransferases, leads us to suggest that IcaC is responsible for the known O-succinylation of PNAG that occurs in staphylococci, identifying a potentially new therapeutic target specific for these bacteria. (C) 2014 Published by Elsevier B. V. on behalf of the Federation of European Biochemical Societies.
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