期刊
FEBS LETTERS
卷 588, 期 23, 页码 4438-4447出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2014.09.045
关键词
miR-185; Breast cancer; Proliferation; Apoptosis; Vegfa
资金
- Natural Science Foundation of China [81370720]
- National Research Institute [2012GJSSJKA03]
MiR-185 expression has been associated with many cancers. However, the roles of miR-185 in human breast cancer remain elusive. Here, we found that miR-185 expression was decreased in human breast cancer tissues compared with healthy tissue controls. Up-regulation of miR-185 inhibited breast cancer cell proliferation and invasion and vice versa. MiR-185 was shown to bind to the 3'-untranslated region (UTR) of vascular endothelial growth factor a (Vegfa), and a significant inverse correlation was found between miR-185 and Vegfa. Vegfa overexpression partially restored the inhibition of cell proliferation and invasion that was induced by miR-185, and vice versa. Additionally, Vegfa expression was found to be high in human breast cancer tissues. Thus, miR-185-mediated Vegfa targeting may be involved in breast cancer formation. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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