期刊
FEBS LETTERS
卷 588, 期 1, 页码 99-104出版社
WILEY
DOI: 10.1016/j.febslet.2013.11.014
关键词
miR-221; RECK; Metastasis; Colorectal cancer
MicroRNAs (miRNAs) have recently emerged as regulators of metastasis. We provide insight into the behavior of miR-221 in colorectal cancer (CRC) metastasis by showing that miR-221 is significantly upregulated in metastatic CRC cell lines and tissues. miR-221 overexpression enhances, whereas miR-221 depletion reduces CRC cell migration and invasion in vitro and metastasis in vivo. We identify RECK as a direct target of miR-221, reveal its expression to be inversely correlated with miR-221 in CRC samples and show that its re-introduction reverses miR-221-induced CRC invasiveness. Collectively, miR-221 is an oncogenic miRNA which may regulate CRC migration and invasion through targeting RECK. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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