期刊
FEBS LETTERS
卷 587, 期 13, 页码 1840-1847出版社
WILEY
DOI: 10.1016/j.febslet.2013.04.027
关键词
Active chromatin hub; Chromosome folding; Nuclear matrix; Macromolecular crowding
资金
- Ministry of Science and Education of the Russian Federation [14.740.12.1344, 16.740.11.0483, 8052]
- Russian Foundation [11-04-00361-a, 11-04-91334-NNIO_a, 12-04-93110, 12-04-33040, 12-04-00036-a, 12-04-0013]
- Presidium of the Russian Academy of Sciences (Grants from the Program on Molecular and Cellular Biology)
- Russian Federation for young scientists [MK-3813.2012.4]
- Dmitri Zimin's Dynasty foundation
The most popular model of gene activation by remote enhancers postulates that the enhancers interact directly with target promoters via the looping of intervening DNA fragments. This interaction is thought to be necessary for the stabilization of the Pol II pre-initiation complex and/or for the transfer of transcription factors and Pol II, which are initially accumulated at the enhancer, to the promoter. The direct interaction of enhancer(s) and promoter(s) is only possible when these elements are located in close proximity within the nuclear space. Here, we discuss the molecular mechanisms for maintaining the close proximity of the remote regulatory elements of the eukaryotic genome. The models of an active chromatin hub (ACH) and an active nuclear compartment are considered, focusing on the role of chromatin folding in juxtaposing remote DNA sequences. The interconnection between the functionally dependent architecture of the interphase chromosome and nuclear compartmentalization is also discussed. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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