期刊
FEBS LETTERS
卷 587, 期 12, 页码 1703-1710出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2013.04.036
关键词
Cell cycle; Evi5; GTPase Activating Protein (GAP); Rab
资金
- NUS Graduate School of Integrative Sciences and Engineering
The Ecotropic viral integration site 5 (Evi5) and Evi5-like (Evi5L) belong to a small subfamily of the Tre-2/Bub2/Cdc16 (TBC) domain-containing proteins with enigmatically divergent roles as modulators of cell cycle progression, cytokinesis, and cellular membrane traffic. First recognized as a potential oncogene and a cell cycle regulator, Evi5 acts as a GTPase Activating Protein (GAP) for Rab11 in cytokinesis. On the other hand, its homologue Evi5L has Rab-GAP activity towards Rab10 as well as Rab23, and has been implicated in primary cilia formation. Recent genetic susceptibility analysis points to Evi5 as an important factor in susceptibility to multiple sclerosis. We discuss below the myriad of cellular functions exhibited by the Evi5 family members, and their associations with disease conditions. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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