期刊
FEBS LETTERS
卷 587, 期 6, 页码 690-697出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2013.01.042
关键词
eIF4E; Cervical cancer; Human papillomavirus; HPV; E6
资金
- Department of Education of Guangdong Province [2012KJCX0057]
- National Natural Science Foundation of China [30670860]
- Guangdong Medical College [STIF201113, B2011012]
- Guangdong Natural Science Foundation [S2012040006383]
Increasing evidence has placed eukaryotic translation initiation factor 4E (eIF4E) at the hub of tumor development and progression. Several studies have reported that eIF4E is over-expressed in cervical cancer; however, the mechanism remains elusive. The results of this study further confirm over-expression of eIF4E in cervical cancer tumors and cell lines, and we have discovered that the transcription of eIF4E is induced by protein E6 of the human papillomavirus (HPV). Moreover, regulation of eIF4E by E6 significantly influences cell proliferation, the cell cycle, migration, and apoptosis. Therefore, eIF4E emerges as a key player in tumor development and progression and a potential target for CC treatment and prevention. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据