期刊
FEBS LETTERS
卷 587, 期 15, 页码 2385-2392出版社
WILEY
DOI: 10.1016/j.febslet.2013.06.005
关键词
miR-142-5p; BTG3; Proliferation; Vascular smooth muscle cell; Neointima hyperplasia
资金
- Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea [A100317, A084869]
- Korea Health Promotion Institute [A100317] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Vascular smooth muscle cell (VSMC) proliferation plays a key role in neointimal hyperplasia and restenosis. Here we report the role of the microRNA miR-142-5p and its downstream target genes on the proliferation of cultured VSMCs. miR-142-5p promoted VSMC proliferation by down-regulating B cell translocation gene 3 (BTG3). We found that BTG3 inhibited the expression of cell cycle regulatory genes and cell growth. As shown by luciferase reporter assay, miR-142-5p bound directly to the 3'-untranslated region of BTG3. Overexpression of miR-142-5p induced expression of cell cycle regulatory genes. Thus, BTG3, a novel, direct target of miR-142-5p, negatively regulates VSMC proliferation. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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