期刊
FEBS LETTERS
卷 588, 期 1, 页码 52-57出版社
WILEY
DOI: 10.1016/j.febslet.2013.10.049
关键词
Natriuretic peptide; N-terminal pro-atrial natriuretic peptide (NT-proANP); Amyloid fibril; Isolated atrial amyloidosis (IAA); Cardiac amyloidose
资金
- University of Athens
- National Hellenic Research Foundation
Isolated atrial amyloidosis (IAA) is a common localized form of amyloid deposition within the atria of the aging heart. The main constituents of amyloid fibrils are atrial natriuretic peptide (ANP) and the N-terminal part of its precursor form (NT-proANP). An 'aggregation-prone' heptapeptide ((114)KLRALLT(120)) was located within the NT-proANP sequence. This peptide self-assembles into amyloid-like fibrils in vitro, as electron microscopy, X-ray fiber diffraction, ATR FT-IR spectroscopy and Congo red staining studies reveal. Consequently, remedies/drugs designed to inhibit the aggregation tendency of this 'aggregation-prone' segment of NT-proANP may assist in prevention/treatment of IAA, congestive heart failure (CHF) or atrial fibrillation (AF). (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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