Article
Oncology
Lili Zhang, Huixiao Chen, Fengxi He, Shiqian Zhang, Aihua Li, Aifeng Zhang, Anqi Zhang
Summary: miR-320a plays an important role in ovarian cancer progression and infiltration, promoting the proliferation, migration, and invasion of EOC cells by targeting RASSF8.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Guolong Liao, He Ma, Yamei Li, Yiyu Sheng, Chujie Chen
Summary: Selenium nanoparticles (SeNPs) have been shown to inhibit the migration and invasion of prostate cancer cells, with miR-155-5p playing a key role in mediating this effect by directly targeting specific proteins. Cell-based results were validated in xenograft mice models, indicating the potential of SeNPs as an anti-tumor agent in prostate cancer treatment.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Cell Biology
Tingting Liu, Jie Wang, Kalpana Subedi, Qijun Yi, Li Zhou, Qing-Sheng Mi
Summary: The study showed that miR-155 plays a crucial role in the development and function of MAIT cells, with its overexpression leading to a decrease in the number and frequency of MAIT cells, promotion of MAIT1 differentiation, and inhibition of MAIT17 differentiation. Lack of miR-155 also affects the differentiation of MAIT cells but without altering their overall frequency, maturation, and function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Aiping Wen, Le Luo, Chengchao Du, Xin Luo
Summary: This study found that miR155HG inhibits the malignant biological behavior of OC cells by targeting the miR-155-5p/TYRP1 axis, providing new insights into the underlying mechanism of OC progression.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, Research & Experimental
Kensuke Sugiura, Yasunori Masuike, Kensuke Suzuki, Alice E. Shin, Nozomu Sakai, Hisahiro Matsubara, Masayuki Otsuka, Peter A. Sims, Christopher J. Lengner, Anil K. Rustgi
Summary: The RNA-binding protein LIN28B is overexpressed in a significant portion of patients with colorectal cancer (CRC) and is associated with poor prognosis. This study uncovered a potentially novel mechanism by which LIN28B regulates colonic epithelial cell-cell junctions and CRC metastasis. LIN28B directly binds to and posttranscriptionally regulates CLDN7 mRNA, leading to enhanced invasion, cell migration, and metastatic liver tumor formation. NOTCH3 was identified as a downstream effector of the LIN28B/CLDN1 axis and necessary for invasion and metastatic liver tumor formation. This discovery provides a promising new therapeutic option for metastatic CRC to the liver.
Article
Cell Biology
Zixu Bao, Ning Zhang, Wanxiang Niu, Maolin Mu, Xiaoming Zhang, Shanshan Hu, Chaoshi Niu
Summary: Exosomes released from glioma stem-like cells (GSCs) containing miR-155-5p can be horizontally transferred to surrounding glioma cells, promoting tumor progression and mesenchymal transition by targeting ACOT12. High expression of miR-155-5p in plasma exosomes is associated with glioma diagnosis and grading, suggesting its potential as a predictive biomarker for glioma.
CELL DEATH & DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Fengjie Li, Zhen Liang, Yongqin Jia, Panyang Zhang, Kaijian Ling, Yanzhou Wang, Zhiqing Liang
Summary: The decreased expression of miR-324-3p inhibits ovarian cancer (OC) proliferation, and this inhibition can be reversed by the upregulated kinase WNK2, which promotes OC cell proliferation and invasion through the activation of the RAS pathway.
Article
Reproductive Biology
Jun Li, Huiran Yue, Wenzhi Li, Guohua Zhu, Tingting Zhu, Ruifang Chen, Xin Lu
Summary: The study identified differential expression of miR-25 and miR-142 in LVSI-positive and LVSI-negative ovarian cancer tumors. High miR-25 expression was associated with better PFS and OS, while high miR-142 expression was linked to reduced OS. Patients with low miR-25 expression and high miR-142 expression benefited significantly from bevacizumab treatment.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yi-Ping Tao, Heng-Yan Zhu, Qian-Yuan Shi, Cai-Xia Wang, Yu-Xin Hua, Han-Yin Hu, Qi-Yin Zhou, Zi-Lu Zhou, Ying Sun, Xiao-Min Wang, Yu Wang, Ya-Ling Zhang, Yan-Jun Guo, Zi-Ying Wang, Xuan Che, Chun-Wei Xu, Xian-Chao Zhang, Michal Heger, Su-Ping Tao, Xin Zheng, Ying Xu, Lei Ao, Ai-Jun Liu, Sheng-Bing Liu, Shu-Qun Cheng, Wei-Wei Pan
Summary: S1PR1 was found to be highly expressed in human ovarian cancer tissues and cells, and its deletion inhibited cancer cell proliferation and migration while promoting cell senescence and sensitivity to chemotherapy. S1P was shown to regulate ovarian cancer cell senescence by modulating the expression of PDK1, LATS1/2, and YAP. The study demonstrates the importance of the S1PR1-PDK1-LATS1/2-YAP signaling axis in the regulation of ovarian cancer cell senescence.
Article
Medicine, Research & Experimental
Febina Ravindran, Anisha Mhatre, Jinsha Koroth, Suchitra Narayan, Bibha Choudhary
Summary: The study aims to understand the epigenetic role of curcumin in inducing cytotoxicity in two molecularly distinct ovarian cancer cell lines. The results show that curcumin activates different miRNA-mRNA regulatory networks to induce multiple modes of cellular cytotoxicity, showcasing its potential as a promising drug candidate for ovarian cancer treatment.
Article
Oncology
Yu-An Chen, Chen-Yu Lu, Wen-Fang Cheng, Kuan-Ting Kuo, Chen-Wei Yu, Hon-Nerng Ho, Hsin-Fu Chen, Szu-Hua Pan
Summary: In patients with ovarian cancer, co-expression of multiple stem-related transcription factors (OCT4, SOX2, and NANOG) is associated with worse overall survival. The reprogrammed iOVCAR-3-OSKM cells demonstrate stemness characteristics, high drug resistance, and migration ability. This iOCIC model may provide a potential strategy for personalized treatment of ovarian cancer in the future.
Article
Cell Biology
Liu Yang, Xing Du, Siqi Wang, Chenggang Lin, Qiqi Li, Qifa Li
Summary: miR-187 maintains TGFBR2 mRNA stability in sow GCs by activating the TGF-beta signaling pathway and inhibiting GC apoptosis. NORHA inhibits the activation of TGF-beta signaling pathway by sponging miR-187. NORFA enhances miR-187 and TGFBR2 expression by inhibiting NORHA and activating NFIX.
CELL DEATH DISCOVERY
(2023)
Article
Oncology
Lucile Yart, Daniel Bastida-Ruiz, Mathilde Allard, Pierre-Yves Dietrich, Patrick Petignat, Marie Cohen
Summary: This study found that cell fusion may be involved in the formation of ovarian PGCCs, and this process is promoted by paclitaxel and UPR activation. Modulating the UPR could be an interesting therapeutic strategy to prevent the formation of PGCCs and therefore limit cancer relapse and drug resistance.
Article
Medicine, Research & Experimental
Tianshui Sun, Fangfang Bi, Zhuonan Liu, Qing Yang
Summary: In ovarian cancer patients, TMEM119 is overexpressed and associated with poor survival. Experimental results indicate TMEM119 promotes proliferation, invasion, and migration of ovarian cancer cells. Additionally, TMEM119 may exert oncogenic effects by regulating PDGFRB expression and activating the PI3K/AKT signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Preety Bajwa, Kasjusz Kordylewicz, Agnes Bilecz, Ricardo R. Lastra, Kristen Wroblewski, Yuval Rinkevich, Ernst Lengyel, Hilary A. Kenny
Summary: Ovarian cancer preferentially metastasizes in association with mesothelial cell-lined surfaces. The presence of mesothelial cells is required for ovarian cancer metastasis, and the interaction between mesothelial cells and ovarian cancer cells leads to alterations in gene expression and cytokine secretion. The secretion of ANGPTL4 by mesothelial cells promotes ovarian cancer metastasis through various mechanisms.
