期刊
FEBS LETTERS
卷 586, 期 23, 页码 4139-4143出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2012.10.010
关键词
Translation control; Internal ribosome entry site (IRES); Cap-independent translation enhancer (CITE); Apoptotic peptidase activating factor 1 (Apaf-1); Etoposide
资金
- Russian Federation [MK-5309.2011.4]
- Russian Foundation for Basic Research (RFBR) [11-04-01010]
We have previously shown that translation driven by the 5' UTR of Apaf-1 mRNA is relatively efficient in the absence of m7G-cap, but no IRES is involved. Nevertheless, it may be speculated that a silent IRES is activated under apoptosis conditions. Here, we show that translation of the mRNA with the Apaf-1 5' UTR is relatively resistant to apoptosis induced by etoposide when eIF4E is sequestered by 4E-BP and eIF4G is partially cleaved. However, translation under these conditions remains governed by 5' end-dependent scanning. We hypothesize that the observed phenomenon is based on the intrinsic low cap-dependence of the Apaf-1 5' UTR. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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