期刊
FEBS LETTERS
卷 586, 期 15, 页码 2043-2048出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2012.03.051
关键词
Genome layout and design; Bacteria; Replication; Transcription; Codon bias; Co-functional gene
资金
- Sixth European Research Framework (GENNETEC project) [034952]
- Seventh European Research Framework (ST-FLOW project) [289326]
- CNRS
- CRIF
- Genopole(R)
- Novartis
Recently the mismatch between our newly acquired capacity to synthetize DNA at genome scale, and our low capacity to design ab initio a functional genome has become conspicuous. This essay gathers a variety of constraints that globally shape natural genomes, with a focus on eubacteria. These constraints originate from chromosome replication (leading/lagging strand asymmetry; gene dosage gradient from origin to terminus; collisions with the transcription complexes), from biased codon usage, from noise control in gene expression, and from genome layout for co-functional genes. On the basis of this analysis, lessons are drawn for full genome design. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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