期刊
FEBS LETTERS
卷 586, 期 21, 页码 3900-3907出版社
WILEY
DOI: 10.1016/j.febslet.2012.09.021
关键词
Measles virus; Phosphoprotein; Nucleoprotein; Phosphorylation; Transcription
资金
- Ministry of Education, Science, Sports, and Culture, Japan
Measles virus phosphoprotein (P protein) is a cofactor of the viral RNA polymerase (L protein) that associates with the nucleoprotein-RNA complex to support viral transcription and replication. Here, we report a significant inverse correlation between the phosphorylation level of MV-P protein and viral transcriptional activity. Upregulation of P protein phosphorylation resulted in reduction of viral transcription. Additionally, we found that strong phosphorylation at S86 and S151 of P protein, which may be generally prevented by association with nucleoprotein, downregulates the viral transcriptional activity. These findings suggest that P protein is involved in regulation of viral transcription through changes in its phosphorylation status. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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