期刊
FEBS LETTERS
卷 586, 期 16, 页码 2563-2569出版社
WILEY
DOI: 10.1016/j.febslet.2012.06.035
关键词
Indole-diterpene; Lolitrem B; Metabolic grid; ltm gene; Endophyte; Symbiosis; Epichloe festucae
资金
- Grant from the Foundation for Research, Science and Technology [C10X0815]
- Massey University
Epichloe festucae Fl1 in association with Lolium perenne synthesizes a diverse range of indole-diterpene bioprotective metabolites, including lolitrem B, a potent tremorgen. The ltm genes responsible for the synthesis of these metabolites are organized in three clusters at a single sub-telomeric locus in the genome of E. festucae. Here we resolve the genetic basis for the remarkable indole-diterpene diversity observed in planta by analyzing products that accumulate in associations containing ltm deletion mutants of E. festucae and in cells of Penicillium paxilli containing copies of these genes under the control of a P. paxilli biosynthetic gene promoter. We propose a biosynthetic scheme to account for this metabolic diversity. (c) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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