期刊
FEBS LETTERS
卷 587, 期 1, 页码 73-81出版社
WILEY
DOI: 10.1016/j.febslet.2012.11.004
关键词
miR-137; Lung cancer; Cdc42; Cdk6
MicroRNAs (miRNA) have emerged as key players in carcinogenesis. Here, we investigated the role of miR-137 in the pathogenesis of lung cancer. The downregulation of miR-137 in lung cancer cells could be rescued following inhibition of DNA methylation. Ectopic expression of miR-137 in lung cancer cells significantly downregulated Cdc42, Cdk6 and induced G1 cell cycle arrest, leading to a significant decrease in cell growth in vivo and in vitro. Further, both Cdc42 and Cdk6 were confirmed as targets of miR-137. Crown Copyright (C) 2012 Published by Elsevier B. V. on behalf of Federation of European Biochemical society. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据