Article
Medicine, General & Internal
Jose-Pablo Serrano-Serra, Trinidad Montero-Vilchez, Agustin Buendia-Eisman, Salvador Arias-Santiago
Summary: The study found that permanent tattoos have a lower skin temperature and higher stratum corneum hydration. Adhesive tattoos showed lower skin temperature, hydration, and total antioxidant capacity, but higher transepidermal water loss. After petrolatum application, the temperature decreased on skin with permanent tattoos, and hydration and transepidermal water loss decreased on skin with adhesive tattoos. Tattooed and non-tattooed skin respond differently to moisturizers.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biology
Juan Wang, Sabine A. Eming, Xiaolei Ding
Summary: This review focuses on the formation of the skin barrier and discusses how mTOR signaling networks regulate epidermal differentiation and skin barrier formation. Understanding metabolic signaling in the epidermis is crucial for developing new pharmacological approaches to promote skin barrier regeneration and treat diseases associated with epidermal barrier defects.
Review
Biochemistry & Molecular Biology
Alain Lefevre-Utile, Camille Braun, Marek Haftek, Francois Aubin
Summary: The epidermis is a living, multilayered barrier with five functional levels, including physical, chemical, microbial, neuronal, and immune levels, which work together to protect the host from external aggression and maintain its integrity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Ariane Dimitrov, Martine Zanini, Helene Zucchi, Samia Boudah, Joaquim Lima, Jeremie Soeur, Laurent Marrot
Summary: The study suggests that polycyclic aromatic hydrocarbons found in ultrafine particles may have a negative impact on skin health, affecting the survival and structure of epidermal cells. Additionally, the use of vitamin C provides significant protection against these harmful effects.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Paula Montero, Javier Milara, Martin Perez-Leal, Cristina Estornut, Ines Roger, Alejandro Perez-Fidalgo, Celia Sanz, Julio Cortijo
Summary: This study demonstrated that paclitaxel affects healthy human epidermal cells, impairing various cellular processes such as inflammation, oxidative stress, apoptosis, and reduced vascular tube formation. Toll-like receptor 4 activation is involved in mediating some of these adverse effects on skin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Dermatology
Mitsuhiro Denda, Shinobu Nakanishi
Summary: Keratinocytes were traditionally believed to only construct a protective barrier in the skin, but recent research has shown that they also have sensory systems capable of detecting environmental changes and expressing neurotransmitters and receptors. Activation of keratinocytes has been found to influence sensory perception in the brain, suggesting they may represent an early stage in brain development during vertebrate evolution.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Milena Wojciechowska, Kinga Scibior, Monika Betyna-Bialek, Ewa Kostrzewska, Oliwia McFarlane
Summary: The study investigated the involvement of periostin (POSTN) in the pathogenesis of psoriasis, finding significantly higher levels of POSTN in psoriasis patients compared to healthy individuals. However, the specific role of POSTN in the development of psoriasis remains unclear, warranting further research to elucidate its mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Paula Montero, Martin Perez-Leal, Jose Alejandro Perez-Fidalgo, Celia Sanz, Cristina Estornut, Ines Roger, Javier Milara, Andres Cervantes, Julio Cortijo
Summary: Skin toxicity caused by paclitaxel could be underestimated as the adverse events may appear asymptomatic. This study found that paclitaxel alters gene and protein expression related to skin markers, and impairs the physical, physiological, and biomechanical properties of the skin in gynecological cancer patients. Prophylactic measures should be taken to prevent these subclinical alterations and potential adverse reactions.
Article
Cell Biology
Hanqian Zhang, Simone Westrom, Per Kappelin, Marie Virtanen, Anders Vahlquist, Hans Torma
Summary: This study re-analyzed two sets of microarray data, identifying 24 upregulated genes and confirming 10 of them to be potentially involved in human epidermal keratinocyte differentiation and important for epidermal repair in a genetic skin disease characterized by barrier failure.
Article
Microbiology
Emma N. Kerr, Bhavya Papudeshi, Miranda Haggerty, Natasha Wild, Asha Z. Goodman, Lais F. O. Lima, Ryan D. Hesse, Amber Skye, Vijini Mallawaarachchi, Shaili Johri, Sophia Parker, Elizabeth A. Dinsdale
Summary: Marine host-associated microbiomes are influenced by both species-specific and habitat-specific factors. The epidermal microbiomes of two ray species, Myliobatis californica and Urobatis halleri, were compared to assess the effects of host phylogeny and habitat. The microbiomes were found to be species-specific, with M. californica showing more variability between individuals. Despite taxonomic differences, the diversity of U. halleri microbiomes remained constant across two locations, suggesting local adaptations. The stingray mucus supported high microbial growth rates and contained novel microbial species with antimicrobial properties.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Agricultural Engineering
Mengxiao Xu, Hanchi Xu, Yalin Sui, Xiaoxiao Yan, Zhaojun Wang, Hong Cui, Hongying Zhang
Summary: A novel member of the homeodomain leucine zipper IV family, NtHDZIPIV9, was found to play a crucial role in the development of the epidermal cuticles in tobacco. Overexpression of NtHDZIPIV9 increased cuticle thickness, pigment content, and leaf surface exudates, while knockout of NtHDZIPIV9 significantly reduced these characteristics.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Review
Cell Biology
Hanxiao Yin, Mingzheng Hu, Dengwen Li
Summary: The epidermis is a barrier in the outermost layer of the skin that protects against pathogens. Basal keratinocytes, acting as stem cells, are crucial for epidermal development and skin damage recovery. Understanding the molecular mechanism of basal keratinocytes in epidermal development and stratification is important for preventing and treating skin lesions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Cell Biology
Andrzej T. Slominski, Radomir M. Slominski, Chander Raman, Jake Y. Chen, Mohammad Athar, Craig Elmets
Summary: The skin, as the largest organ in the human body, plays a crucial role in maintaining the body's homeostasis. It is regulated by local neuroendocrine and immune systems, with signaling molecules produced by resident and immune cells. Neurotransmitters, endocrine factors, neuropeptides, and cytokines released from nerve endings are involved in the skin's response to stress. The skin acts as a barrier against environmental stressors and communicates with other systems in the body to maintain overall homeostasis. Disturbances in these systems can lead to various skin pathologies.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biology
Adnan Mahly, Krishnanand Padmanabhan, Arad Soffer, Jonathan Cohen, Jana Omar, Ronit Sagi-Eisenberg, Chen Luxenburg
Summary: This study identifies a crucial role for anillin in orchestrating epidermal morphogenesis and reveals a novel role for anillin in mitotic rounding, a process that governs cell shape, fate, and tissue morphogenesis.
Article
Cell Biology
Romy Winkler, Marianne Quaas, Stefan Glasmacher, Uwe Wolfrum, Torsten Thalheim, Joerg Galle, Knut Krohn, Thomas M. Magin, Gabriela Aust
Summary: The expression and function of GPR115 in skin, specifically in epidermal differentiation, has been largely unknown. This study reveals that GPR115 is present in a small subset of keratinocytes in the stratified epidermis, and its expression is delayed in psoriatic skin. Deletion of GPR115 leads to reduced keratinocyte stratification, suggesting its role in epidermal differentiation. Intriguingly, endogenous GPR115 localizes along keratin filaments in a regular pattern, indicating a previously unknown function in regulating epidermal differentiation and keratin expression.
Letter
Dermatology
Thiviyani Maruthappu, Lisa A. McGinty, Diana C. Blaydon, Benjamin Fell, Arlo Maatta, Rebecca Duit, Tim Hawkins, Kristin M. Braun, Michael A. Simpson, Edel A. O'Toole, David P. Kelsell
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Article
Oncology
Lorna McInroy, Arto Maeaettae
EXPERIMENTAL CELL RESEARCH
(2011)
Article
Developmental Biology
Gavin D. Richardson, Katherine A. Fantauzzo, Hisham Bazzi, Arto Maatta, Colin A. B. Jahoda
GENE EXPRESSION PATTERNS
(2009)
Article
Cell Biology
Nkemcho Ojeh, Vanja Pekovic, Colin Jahoda, Arto Maatta
JOURNAL OF CELL SCIENCE
(2008)
Article
Dermatology
Nkemcho Ojeh, Katri Hiilesvuo, Anni Waerri, Markku Salmivirta, Tiina Henttinen, Arto Maeaettae
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2008)
Review
Oncology
C. A. Ambler, A. Maatta
JOURNAL OF PATHOLOGY
(2009)
Article
Dermatology
Rebecca Duit, Tim J. Hawkins, Arto Maatta
EXPERIMENTAL DERMATOLOGY
(2019)
Article
Anatomy & Morphology
Mathilde Roger, Nicola Fullard, Lydia Costello, Steven Bradbury, Ewa Markiewicz, Steven O'Reilly, Nicole Darling, Pamela Ritchie, Arto Maatta, Iakowos Karakesisoglou, Glyn Nelson, Thomas von Zglinicki, Teresa Dicolandrea, Robert Isfort, Charles Bascom, Stefan Przyborski
JOURNAL OF ANATOMY
(2019)
Article
Biochemical Research Methods
Naomi A. Carne, Steven Bell, Adrian P. Brown, Arto Maatta, Michael J. Flagler, Adam M. Benham
MOLECULAR & CELLULAR PROTEOMICS
(2019)
Article
Dermatology
Simeon Johnson, Kevin Cowley, Timothy J. Hawkins, Arto Maatta
EXPERIMENTAL DERMATOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Bin Fang, Patrick D. Card, Junjun Chen, Lijuan Li, Timothy Laughlin, Bradley Jarrold, Wenzhu Zhao, Adam M. Benham, Arto T. Maatta, Timothy J. Hawkins, Tomohiro Hakozaki
Summary: Sallow and/or dull skin is caused by the yellow components of skin tone, specifically bilirubin. Recent studies have shown that bilirubin can be synthesized in keratinocytes, and oxidative stress can enhance its production. Furthermore, a compound combination called SDL has been found to reduce bilirubin levels and mitigate yellowish and dull skin appearance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Arto Maatta, Rebecca Nixon, Neil Robinson, Carrie A. Ambler, Kirsty Goncalves, Victoria Maltman, Stefan Przyborski
Summary: Retinoid signaling plays a crucial role in regulating skin and its appendages. Synthetic retinoids have been developed as therapeutic options for skin disorders. In this study, the synthetic retinoid EC23 was found to stimulate epidermal and hair follicle growth more potently than the natural retinoid all-trans retinoic acid (ATRA).
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Chemistry, Applied
Jennifer M. Marsh, Shane Whitaker, Tim Felts, William Shearouse, Mike Vatter, Arto Maatta, Matthew Thompson, Timothy J. Hawkins
JOURNAL OF COSMETIC SCIENCE
(2018)
Article
Cell Biology
Lisa M. Sevilla, Rachida Nachat, Karen R. Groot, John F. Klement, Jouni Uitto, Philippe Djian, Arto Maatta, Fiona M. Watt
JOURNAL OF CELL BIOLOGY
(2007)
