Editorial Material
Oncology
Sylvain Peuget, Galina Selivanova
Summary: p53 is a complex cell signaling hub that controls the expression of multiple target genes in response to different stimuli, with the exact code by which p53 integrates these stresses into transcriptional responses still unclear. Regulation of p53 at various levels leads to a wide diversity in p53 complexes on target promoters, providing adaptability to its transcriptional program. Understanding the mechanisms by which p53 selectively directs desired outcomes in cancer cells is crucial as p53-targeted therapies progress, with further investigations needed on cell type- and stimuli-dependent transcriptional outcomes by p53.
Article
Plant Sciences
Wei-Gui Luo, Qi-Wen Liang, Yi Su, Chao Huang, Bei-Xin Mo, Yu Yu, Lang-Tao Xiao
Summary: Auxin, an important phytohormone in plant, negatively regulates chlorophyll biosynthesis by suppressing the expression of chlorophyll biosynthesis genes such as PORA and GUN5 with the help of IAA14. The yuc2 yuc6 double mutant showed higher chlorophyll content and improved photosynthetic efficiency, indicating the inhibitory role of auxin in chlorophyll metabolism. Our findings provide new insights into the interplay between auxin signaling and chlorophyll metabolism.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Oncology
Shujun Han, Yuwei Yan, Yibo Ren, Yiming Hu, Yan Wang, Lei Chen, Zhe Zhi, Yan Zheng, Yongping Shao, Jiankang Liu
Summary: SAMMSON, a long noncoding RNA, plays a crucial role in promoting the growth and survival of human melanoma cells. It regulates adaptive resistance to RAF inhibitors in melanoma by modulating the CARF-p53 signaling axis.
Review
Genetics & Heredity
Rinka Nakajima, Lin Zhao, Yaxuan Zhou, Mashiro Shirasawa, Ayato Uchida, Hikaru Murakawa, Mariana Fikriyanti, Ritsuko Iwanaga, Andrew P. Bradford, Keigo Araki, Tomoko Warita, Kiyoshi Ohtani
Summary: Transcription factor E2F, the main target of the tumor suppressor pRB, plays essential roles in cell proliferation and tumor suppression. In almost all cancers, pRB is inactivated, leading to enhanced E2F activity. Trials have been conducted to suppress enhanced E2F activity for targeted cancer therapy, but it may also affect normal growing cells due to the shared mechanism of growth stimulation.
Article
Multidisciplinary Sciences
Amit Jangid, Md Zubbair Malik, Ram Ramaswamy, R. K. Brojen Singh
Summary: In the study, it was found that the p53 regulatory network exhibits four distinct dynamical states, including active, apoptotic, pre-malignant, and cancer states, depending on the nature and level of the external stress signal. Transitions between these states are unidirectional and irreversible, with the system moving to an irreversible cancerous state under significantly large stress.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Pingzhao Zhang, Kun Gao, Liang Zhang, Huiru Sun, Xiaying Zhao, Yajuan Liu, Zeheng Lv, Qing Shi, Yingji Chen, Dongyue Jiao, Yao Li, Wei Gu, Chenji Wang
Summary: This study demonstrates the important role of CRL2-KLHDC3 E3 ubiquitin ligase complex in regulating the stability of p14(ARF) protein, with KLHDC3 promoting ubiquitin-proteasomal degradation of p14(ARF) to suppress ferroptosis and support tumor growth. The findings suggest that overexpression of KLHDC3 likely contributes to cancer progression by suppressing the p14(ARF)-NRF2-SLC7A11 regulatory pathway.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Chemistry, Multidisciplinary
Fangzhou Li, Delin Chen, Qianqian Sun, Jiale Wu, Yaling Gan, Kam W. Leong, Xing-Jie Liang
Summary: This study explores the inhibition of ARF expression in p53-wild-type tumors and proposes the use of ARF-mimetic MDM2-targeting reassembly peptide nanoparticles (MtrapNPs) for p53-based tumor therapy. The MtrapNPs trap MDM2 and activate p53, leading to the inhibition of p53-wild-type tumors. The study also demonstrates the therapeutic effects of using MtrapNPs to deliver arsenic trioxide for p53-mutated tumor treatment.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Jorge Zuniga-Hernandez, Claudio Meneses, Macarena Bastias, Miguel L. Allende, Alvaro Glavic
Summary: This study analyzes the role of Drosophila DAxud1 in cell survival and apoptosis. It identifies the genes associated with apoptosis and the Wnt pathway that DAxud1 is present in. Furthermore, it reveals a DNA-binding motif in the promoters of these genes and demonstrates the repressive role of DAxud1 on these genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Fredy Kurniawan, Neha Chetlangia, Mohammad Kamran, Christophe E. Redon, Lorinc Pongor, Qinyu Sun, Yo-Chuen Lin, Vijay Mohan, Oways Shaqildi, Darya Asoudegi, Qinyu Hao, Abid Khan, Mirit Aladjem, Kannanganattu Prasanth, Supriya G. Prasanth
Summary: BEND3, a quadruple BEN domain-containing protein, is highly expressed in pluripotent cells and plays a crucial role in regulating chromatin function and transcription repression, thereby contributing to normal development and preventing differentiation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Samantha Mendonsa, Nicolai von Kuegelgen, Lucija Bujanic, Marina Chekulaeva
Summary: Toxic gain-of-function mutations in aminoacyl-tRNA synthetases cause degradation of peripheral motor and sensory axons known as Charcot-Marie-Tooth (CMT) disease. These mutations interfere with translation by depleting glycyl-tRNA pool and inhibiting ribosomal A-site accommodation, leading to ribosome pausing and activation of translational repression mechanisms involving the eIF2α subunit and the integrated stress response. This results in a translational repression affecting both elongation and initiation processes.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chia- Lin, Shie-Shan Wang, Chien-Hui Hung, Pey-Jium Chang, Lee-Wen Chen
Summary: The Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded ORF50 protein negatively regulates MDM2 expression through repressing Sp1- and p53-mediated transactivation. This reciprocal negative regulation between ORF50 and MDM2 provides insights into the regulatory mechanisms involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Samantha Mendonsa, Nicolai von Kuegelgen, Lucija Bujanic, Marina Chekulaeva
Summary: Toxic gain-of-function mutations in aminoacyl-tRNA synthetases cause translational repression in CMT-GARS mutant through inhibiting elongation and activating initiation via the integrated stress response.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yanxia Wu, Yanxi Sun, Binchu Xu, Mo Yang, Xingwu Wang, Xiaocheng Zhao
Summary: The lncRNA SCARNA10 interacts with the DNA binding domain (DBD) of the tumor suppressor p53, promoting its acetylation modification and activating p53-mediated transcriptional activity. This involvement of SCARNA10 in various cellular processes such as cell cycle arrest, apoptosis, DNA repair, cell metabolism, and ferroptosis highlights its importance in tumor suppression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Cell Biology
Che-Pei Kung, Jason D. Weber
Summary: The relationship between P53, MDM2, and ARF plays a crucial role in tumor suppression mechanisms, but our understanding of this relationship needs to be updated in order to develop more effective cancer treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Stefanie Schuller, Jan Sieker, Philip Riemenschneider, Bianca Koehler, Elisabeth Drucker, Sofia M. E. Weiler, Daniel Dauch, Carsten Sticht, Benjamin Goeppert, Stephanie Roessler, Silvia Ribback, Kai Breuhahn, Falko Fend, Frank Dombrowski, Kerstin Singer, Stephan Singer
Summary: The tumor suppressor protein P53 plays a crucial role in preventing liver cancer development, and it negatively regulates the expression of HELLS, an important regulator in liver cancer. The regulatory mechanism involves the induction of P21 and repression of FOXM1, resulting in the downregulation of HELLS expression. This study provides new insights into the epigenetic regulation of liver cancer and the tumor suppressive function of P53.
Article
Multidisciplinary Sciences
Shaoxun Xiang, Hao Gu, Lei Jin, Rick F. Thorne, Xu Dong Zhang, Mian Wu
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Mathematical & Computational Biology
Muhammad Riaz Khan, Ihtisham Bukhari, Ranjha Khan, Hafiz Muhammad Jafar Hussain, Mian Wu, Rick Francis Thorne, Jinming Li, Guangzhi Liu
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2019)
Article
Multidisciplinary Sciences
Pengfei Zhang, Limian Cao, Rongbin Zhou, Xiaolu Yang, Mian Wu
NATURE COMMUNICATIONS
(2019)
Article
Cell Biology
Qidong Li, Yichun Wang, Shuang Wu, Zhong Zhou, Xiaojuan Ding, Ronghua Shi, Rick F. Thorne, Xu Dong Zhang, Wanglai Hu, Mian Wu
Article
Biochemistry & Molecular Biology
Cheng Lin Xu, Ben Sang, Guang Zhi Liu, Jin Ming Li, Xu Dong Zhang, Lian Xin Liu, Rick F. Thorne, Mian Wu
NUCLEIC ACIDS RESEARCH
(2020)
Article
Multidisciplinary Sciences
Aoxing Cheng, Peng Zhang, Bo Wang, Dongdong Yang, Xiaotao Duan, Yongliang Jiang, Tian Xu, Ya Jiang, Jiahui Shi, Chengtao Ding, Gao Wu, Zhihong Sang, Qiang Wu, Hua Wang, Mian Wu, Zhiyong Zhang, Xin Pan, Yue-yin Pan, Ping Gao, Huafeng Zhang, Cong-zhao Zhou, Jing Guo, Zhenye Yang
NATURE COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Xuedan Sun, Rick Francis Thorne, Xu Dong Zhang, Miao He, Jinming Li, Shanshan Feng, Xiaoying Liu, Mian Wu
Review
Oncology
Xiaoying Liu, Shanshan Feng, Xu Dong Zhang, Jinming Li, Kaiguang Zhang, Mian Wu, Rick F. Thorne
Article
Oncology
Song Chen, Rick F. Thorne, Xu Dong Zhang, Mian Wu, Lianxin Liu
Summary: This review highlights the important roles of the TP53 gene and its protein product, p53, in tumor development, discussing how ncRNAs contribute to tumorigenesis by modulating levels and activity of p53, and their roles within the p53 regulatory network.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Mingyue Li, Rick Francis Thorne, Ronghua Shi, Xu Dong Zhang, Jingmin Li, Jingtong Li, Qingyuan Zhang, Mian Wu, Lianxin Liu
Summary: This study reveals that DDIT3, a stress-responsive transcription factor, plays a crucial role in promoting glycolysis and suppressing mitochondrial respiration in response to glutamine deprivation, enabling tumor cells to survive metabolic stress induced by glutamine starvation.
Article
Multidisciplinary Sciences
Ruijie Wang, Leixi Cao, Rick Francis Thorne, Xu Dong Zhang, Jinming Li, Fengmin Shao, Lirong Zhang, Mian Wu
Summary: GIRGL is a long noncoding RNA induced during glutamine starvation, associated with translational suppression of GLS1. Cellular GIRGL levels are balanced by transactivation by c-JUN and negative stability regulation by HuR/Ago2. Elevated GIRGL levels drive formation of a complex between CAPRIN1 dimers and GLS1 mRNA, promoting liquid-liquid phase separation of CAPRIN1 and stress granule formation.
Article
Multidisciplinary Sciences
Fan Yang, Bogdan Tanasa, Rudi Micheletti, Kenneth A. Ohgi, Aneel K. Aggarwal, Michael G. Rosenfeld
Summary: PAS RNAs act as key gatekeepers for a broad transcriptional pause release program, mediating gene regulation through RNA structure and enabling the activation of target genes.
Article
Medicine, Research & Experimental
Tian Shuai, Muhammad Riaz Khan, Xu Dong Zhang, Jingmin Li, Rick Francis Thorne, Mian Wu, Fengmin Shao
Summary: This study demonstrates that the splice variant TRMP-S of the long noncoding RNA RP11-369C8.1 inhibits p27 expression through distinct mechanisms, including stabilizing UHRF1 protein levels and preventing interactions between p53 mRNA and RPL26.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Youming Zhu, Leu Jin, Ronghua Shi, Jinming Li, Yan Wang, Li Zhang, Chao-Zhao Liang, Vinod K. Narayana, David P. De Souza, Rick F. Thorne, Li Rong Zhang, Xu Dong Zhang, Mian Wu
Summary: This study reveals a novel long noncoding RNA (lncRNA) called gLINC that acts as a backbone for the formation of a metabolon involving glycolytic enzymes and lactate dehydrogenase A. The gLINC metabolon enhances glycolytic flux, ATP production, and cell survival under serine deprivation. Overexpression of gLINC in cancer cells promotes xenograft growth in mice on a serine-deprived diet, suggesting its role in cancer cell adaptation.
Review
Biochemistry & Molecular Biology
Fan Yang
Summary: This article summarizes recent technological advances in the accurate detection of PAS RNA and discusses the mechanisms of PAS RNA biogenesis, emphasizing the important role of its structure in transcription and chromatin regulation.
