Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells

It has been demonstrated that potassium channels (K+ channels) play significant roles in some malignant phenotypes. Here, we provide the first evidence that treatment with glybenclamide, an ATP-sensitive K+ channel blocker, inhibited cell migration in an ovarian clear cell carcinoma cell line, ES-2. Treatment with glybenclamide or knockdown by siRNA targeted against K+ channel sub-units demonstrated the suppression of ovarian cancer cell invasion, which occurred via inhibition of PDGF-AA secretion. Therefore, our findings suggest that K+ channel blockers may be useful chemotherapeutic drugs for blocking the invasiveness of ovarian cancers. (c) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.