期刊
FEBS LETTERS
卷 586, 期 13, 页码 1778-1782出版社
WILEY
DOI: 10.1016/j.febslet.2012.04.060
关键词
SREBP; Fatty acid; Cholesterol; Flavanone
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
Sterol regulatory element-binding proteins (SREBPs) are major transcription factors that regulate the expression of genes involved in fatty acid and cholesterol biosynthesis. Here we show that 4'-hydroxyflavanone (4'-HF) impairs the fatty acid synthase promoter activity and reduces the activation of SREBPs and their target gene expression in human hepatoma Huh-7 cells. Moreover, 4'-HF suppresses de novo fatty acid and cholesterol synthesis. This study identifies 4'-HF as an inhibitor of SREBP maturation and lipid synthesis, and provides evidence that 4'-HF may have major potential as a pharmaceutical preparation against hepatic steatosis and dyslipidemia. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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