期刊
FEBS LETTERS
卷 585, 期 23, 页码 3603-3610出版社
WILEY
DOI: 10.1016/j.febslet.2011.07.043
关键词
Regulatory T-cells (Tregs); Autoimmunity; SLE; RA
资金
- Versus Arthritis [18882] Funding Source: researchfish
- Arthritis Research UK [18882] Funding Source: Medline
- Versus Arthritis [18882] Funding Source: Medline
Regulatory T-cells (Tregs) are the guardians of peripheral tolerance acting to prevent autoimmune diseases such as systemic lupus erythomatosus (SLE) and rheumatoid arthritis ( RA). Defects in Tregs have been reported in these two diseases despite significant differences in their clinical phenotype and pathogenesis. In both diseases the potency of Treg fails to keep pace with the activation of effector cells and are unable to resist the ensuing inflammation. This review will discuss the phenotypic, numeric, and functional abnormalities in Tregs and their role in patients and murine models of SLE and RA. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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