期刊
FEBS LETTERS
卷 586, 期 3, 页码 235-241出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2011.12.016
关键词
Cardiolipin; Apoptosis; Mitochondria; Cardiolipin remodeling; Cardiolipin oxidation; Mitochondria-targeted triphenylphosphonium oleic acid ester
资金
- NIH [U19AIO68021, HL70755, HL094488, ES020693]
- NIOSH [OH008282]
Peroxidation of cardiolipin in mitochondria is essential for the execution of apoptosis. We suggested that integration of oleic acid into cardiolipin generates non-oxidizable cardiolipin species hence protects cells against apoptosis. We synthesized mitochondria-targeted triphenylphosphonium oleic acid ester. Using lipidomics analysis we found that pretreatment of mouse embryonic cells with triphenylphosphonium oleic acid ester resulted in decreased contents of polyunsaturated cardiolipins and elevation of its species containing oleic acid residues. This caused suppression of apoptosis induced by actinomycin D. Triacsin C, an inhibitor of acyl-CoA synthase, blocked integration of oleic acid into cardiolipin and restored cell sensitivity to apoptosis. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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