期刊
FEBS LETTERS
卷 585, 期 19, 页码 3079-3085出版社
WILEY
DOI: 10.1016/j.febslet.2011.08.034
关键词
Endogenous siRNA; Dicer-2; Stress response; Lifespan; Metabolic homeostasis; Drosophila
资金
- Seoul Scholarship Foundation
- National Research Foundation of Korea (NRF)
- Korea government [KRF-2008-313-C00640]
- Ministry of Education, Science, and Technology of Korea
- KOBIC
Small non-coding RNAs regulate gene expression in a sequence-specific manner. In Drosophila, Dicer-2 (Dcr-2) functions in the biogenesis of endogenous small interfering RNAs (endo-siRNAs). We identified 21 distinct proteins that exhibited a >= 1.5-fold change as a consequence of loss of dcr-2 function. Most of these were metabolic genes implicated in stress resistance and aging. dcr-2 Mutants had reduced lifespan and were hypersensitive to oxidative, endoplasmic reticulum, starvation, and cold stresses. Furthermore, loss of dcr-2 function led to abnormal lipid and carbohydrate metabolism. Our results suggest roles for the endo-siRNA pathway in metabolic regulation and defense against stress and aging in Drosophila. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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