期刊
FEBS LETTERS
卷 585, 期 20, 页码 3303-3309出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2011.09.015
关键词
Mir-143; Pleiotrophin; 3T3-L1 preadipocyte; Adipogenesis; Rare codon
资金
- National Natural Science Foundation of China [30871428]
Adipogenic differentiation of preadipocytes is a complex process regulated by various factors including miRNAs and cytokines. MiR-143 is a well known miRNA that enhances adipogenesis. Pleiotrophin (PTN), a heparin-binding growth factor, plays a negative role in adipogenesis. In this investigation, we demonstrate that PTN is a target gene of miR-143 during adipogenic differentiation in 3T3-L1 preadipocytes. MiR-143 down regulates PTN expression through interaction with a target site of miR-143 in the coding region of mouse PTN. The rare codons upstream of the target site regulate miR143-induced translational knockdown of PTN, which provides more insight into the mechanism of adipogenic differentiation. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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