期刊
FEBS LETTERS
卷 584, 期 13, 页码 2921-2925出版社
WILEY
DOI: 10.1016/j.febslet.2010.05.011
关键词
Green tea polyphenol; Glutamate excitotoxicity; Motor neuron; Spinal cord organotypic culture; Amyotrophic lateral sclerosis
资金
- Natural Science Foundation of China [30670732, 30870882, 30900460]
- Science and Technological department of Hebei Province [08966105D]
Epigallocatechin-3-gallate (EGCG) is a major component of green tea polyphenols which displays potential properties of anticancer and neuroprotection. Here we show that protection of motor neuron by EGCG is associated with regulating glutamate level in organotypic culture of rat spinal cord. In this model, EGCG blocked glutamate excitotoxicity caused by threohydroxyaspartate, an inhibitor of glutamate transporter. This property of EGCG may be not due to its intrinsic antioxidative activity, because another antioxidant could not regulate glutamate level under the same condition. These results show that EGCG may be a potential therapeutic candidate for neurodegenerative diseases involving glutamate excitotoxicity such as ALS. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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