期刊
FEBS LETTERS
卷 584, 期 8, 页码 1623-1627出版社
WILEY
DOI: 10.1016/j.febslet.2010.03.026
关键词
Coiled-coil; Intrinsically disordered protein; Structure prediction; Protein evolution
资金
- Hungarian Scientific Research Fund [OTKA F68079, K72973, K61784, NI68466]
- ICGEB [CRP/HUN09-03]
- Janos Bolyai Research Fellowship
Here we report a thorough analysis of cross-predictions between coiled-coil and disordered protein segments using various prediction algorithms for both sequence classes. Coiled-coils are often predicted to be unstructured, consistent with their obligate multimeric nature, whereas reverse cross-predictions are rare due to the regularity of coiled-coil sequences. We propose the simultaneous use of the programs COILS and IUPRED to achieve acceptable prediction accuracy and minimize the extent of cross-predictions. The relevance of observed cross-predictions might be that disordered sequences can adopt coiled-coil conformation relatively easily during protein evolution. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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