Article
Cell Biology
Malgorzata Tokarska-Schlattner, Laurence Kay, Pascale Perret, Raffaella Isola, Stephane Attia, Frederic Lamarche, Cindy Tellier, Cecile Cottet-Rousselle, Amjad Uneisi, Isabelle Hininger-Favier, Marc Foretz, Herve Dubouchaud, Catherine Ghezzi, Christian Zuppinger, Benoit Viollet, Uwe Schlattner
Summary: AMPK, a key regulator of energy homeostasis, plays important roles in maintaining cardiac function under increased workload conditions. Deletion of AMPK genes in cardiomyocytes did not affect heart function under physiological conditions, but led to alterations in response to increased workload. AMPK deletion also resulted in decreased basal metabolic rate and locomotor activity, along with changes in cardiac mitochondrial function and bioenergetics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tiange Li, Han Gong, Biyuan Zhan, Xueying Mao
Summary: Chitosan oligosaccharides (COS) attenuate hepatic steatosis by suppressing lipid synthesis and enhancing fatty acid oxidation. AMP-activated protein kinase (AMPK) is involved in the beneficial effects of COS on hepatic steatosis.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biology
Sandy MacMillan, Andrew P. Holmes, Mark L. Dallas, Amira D. Mahmoud, Michael J. Shipston, Chris Peers, D. Grahame Hardie, Prem Kumar, A. Mark Evans
Summary: This study reveals that LBK1 is a critical regulator of carotid body chemosensing, highlighting a difference in dependency on LKB1 and AMPK between the carotid body and the hypoxic ventilatory response.
COMMUNICATIONS BIOLOGY
(2022)
Article
Plant Sciences
Kaile Zong, Kewei Xu, Xingjiang Zhang, Pan Wang, Zhekun Wang, Shan Yang, Huijuan Li, Hui Ke, Shengsheng He, Yunwei Hu, Yuyo Go, Xi Hui Felicia Chan, Jianxin Wu, Qing Huang
Summary: This study investigated the mechanisms of Huangqin Tang in the treatment of skin lipid accumulation using network pharmacology and in vitro experiments. The results revealed that Huangqin Tang improves lipogenesis in SZ95 sebocytes partially through the AMPK signaling pathway, indicating its potential in the treatment of acne.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Dorota Rogacka, Agnieszka Piwkowska
Summary: Podocytes and their foot processes are crucial for regulating glomerular permeability, with disturbances in podocyte function playing a central role in the development of proteinuria in diabetic nephropathy. Metformin, an oral antidiabetic agent, has potential beneficial effects on diabetic kidney function in addition to lowering glucose levels. Additionally, the activation of AMPK is a key mechanism of action of metformin in protecting against pathological changes in podocytes induced by hyperglycemia.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Geriatrics & Gerontology
Ming-Rui Du, Quan-You Gao, Chen-Lin Liu, Lin-Ya Bai, Tian Li, Fei-Long Wei
Summary: Metformin, as a first-line hypoglycemic drug, not only has proven hypoglycemic effects, but also exhibits cardioprotective, anti-inflammatory, and anticancer activities. It has been increasingly recognized for its potential in preventing and treating neurodegenerative diseases. Research suggests that metformin can prevent the progression of neurodegenerative diseases by regulating various cellular processes. However, there are also theories proposing a two-sided effect of metformin that may accelerate the progression of neurodegenerative diseases. This review examines both animal experiments and clinical studies to discuss the potential application of metformin in neurodegenerative diseases.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yi Ren, Jiaqing Chen, Peishi Chen, Qi Hao, Leng-Kuan Cheong, Mingzhu Tang, Lian-Lian Hong, Xuan-Yu Hu, Celestial T. Yap, Boon-Huat Bay, Zhi-Qiang Ling, Han -Ming Shen
Summary: Mutations in LKB1 lead to increased susceptibility of NSCLC cells to glucose starvation-induced cell death, which triggers oxidative stress and AMPK protein oxidation, eventually resulting in cell death. This process can be effectively reversed and rescued by 2DG, A769662, and NAC.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Masahiro Takahara, Akinobu Takaki, Sakiko Hiraoka, Kensuke Takei, Eriko Yasutomi, Shoko Igawa, Shumpei Yamamoto, Shohei Oka, Masayasu Ohmori, Yasushi Yamasaki, Toshihiro Inokuchi, Hideaki Kinugasa, Keita Harada, Heiichiro Udono, Hiroyuki Okada
Summary: Metformin, a drug commonly used for type 2 diabetes, has been found to suppress intestinal inflammation and improve inflammatory bowel disease (IBD) by activating AMP-activated protein kinase (AMPK). This study suggests that AMPK may be a key molecule in regulating mucosal immunity and inflammation, and AMPK-activating drugs like metformin could be potential therapeutic agents for the treatment of IBD.
Article
Virology
Luis Didier Gonzalez-Garcia, Macario Martinez-Castillo, Tania Allin Vargas-Pavia, Jose Manuel Ulloa-Aguilar, Haruki Arevalo-Romero, Guadalupe Leon-Reyes, Addy Cecilia Helguera-Repetto, Julio Garcia-Cordero, Moises Leon-Juarez
Summary: Respiratory syncytial virus (RSV) is commonly associated with childhood upper respiratory tract infections, with lipid composition and AMPK activation being key factors in RSV infection. Studies have shown that RSV infection leads to inhibition of AMPK activity, promoting downstream lipogenic effector activation and cellular lipid synthesis in HEp-2 cells.
ARCHIVES OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shelby E. Compton, Susan M. Kitchen-Goosen, Lisa M. DeCamp, Kin H. Lau, Batsirai Mabvakure, Matthew Vos, Kelsey S. Williams, Kwok-Kin Wong, Xiaobing Shi, Scott B. Rothbart, Connie M. Krawczyk, Russell G. Jones
Summary: In this study, the researchers identified CRTC2 as an epigenetic driver of inflammatory potential downstream of LKB1 mutations. They found that LKB1 loss sensitizes cells to inflammatory stimuli, leading to increased production of cytokines and chemokines. Mechanistically, CRTC2 cooperates with CBP/p300 to deposit histone acetylation marks at inflammatory gene loci, promoting cytokine expression.
Article
Cardiac & Cardiovascular Systems
Jinxing Hu, Zeqi Zheng, Xuelian Li, Bingong Li, Xingjun Lai, Na Li, Shufang Lei
Summary: Metformin plays a role in reducing endothelial cell injury and suppressing endothelial-mesenchymal transition induced by hypoxia, by activating the AMPK pathway, increasing p-AMPK, and inhibiting mammalian target of rapamycin.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Fiona M. Russell, David Grahame Hardie
Summary: AMP-activated protein kinase (AMPK) plays a crucial role in regulating cellular energy balance by promoting ATP production and inhibiting cell growth. It may restrain aberrant growth before tumorigenesis, but support the survival of cancer cells once cancer has arisen.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Malgorzata Beresewicz-Haller, Olga Krupska, Pawel Bochomulski, Danuta Dudzik, Anita Checinska, Wojciech Hilgier, Coral Barbas, Krzysztof Zablocki, Barbara Zablocka
Summary: The study found that mitochondrial GLS1 activity against ischemic episodes is regulated by PKC beta II. Through the modulation of GLS1 activity and remodeling of mitochondria after exposure to ischemia-reperfusion, the hippocampal CA2-4 and DG regions show strong resistance, while the susceptible CA1 region does not experience the same changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Sarah E. Pierce, Jeffrey M. Granja, M. Ryan Corces, Jennifer J. Brady, Min K. Tsai, Aubrey B. Pierce, Rui Tang, Pauline Chu, David M. Feldser, Howard Y. Chang, Michael C. Bassik, William J. Greenleaf, Monte M. Winslow
Summary: The study reveals the significant role of the tumor suppressor gene LKB1 in lung cancer, showing its impact on metastatic progression through the mechanism of SOX17-mediated epigenetic changes.
NATURE CELL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kai Lou, Pei Sun, Chunxue Zhang, Qiang Jiang, Shuguang Pang
Summary: Accumulating evidence has shown that metformin improves hypertriglyceridemia by regulating DGAT2 and XBP1 expression in the liver, through activation of AMPK. These findings suggest that XBP1 may be a new metabolic mediator for metformin treatment of hypertriglyceridemia and associated metabolic diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
