Article
Biochemistry & Molecular Biology
Mohammad Irshad Reza, Anees A. Syed, Sanjana Kumariya, Pragati Singh, Athar Husain, Jiaur R. Gayen
Summary: The research suggests that PST can induce the aggregation of IAPP in the pancreas, liver, and skeletal muscle, potentially leading to insulin resistance and type 2 diabetes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Immunology
Anne-Cathrine S. Vogt, Elisa S. Roesti, Mona O. Mohsen, Ainars Leonchiks, Monique Vogel, Martin F. Bachmann
Summary: Type 2 Diabetes Mellitus is a chronic progressive disease characterized by insulin resistance and insufficient insulin secretion. Research suggests that monoclonal antibody therapy targeting amyloidogenic aggregates may be a potential treatment for T2DM.
Review
Biochemistry & Molecular Biology
Shahab Hassan, Kenneth White, Cassandra Terry
Summary: This article summarizes the misfolding of human islet amyloid polypeptide (hIAPP) and its impact on type 2 diabetes mellitus, providing insights into the molecular basis of misfolding events and their role in organ damage. Understanding these issues is crucial for developing better therapeutic approaches.
BIOSCIENCE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Lakshan Manathunga, Rehana Akter, Alexander Zhyvoloup, Carlos Simmerling, Daniel P. P. Raleigh
Summary: Amyloids are protein deposits implicated in various diseases. Disrupting the tight packing in amyloid fibrils affects their formation kinetics. Substitutions with larger amino acids disrupt packing and destabilize fibril structures, while specific substitutions can enhance or slow down amyloid formation.
Review
Chemistry, Multidisciplinary
Sabine Szunerits, Amar Abderrahmani, Rabah Boukherroub
Summary: Nanotechnology is revolutionizing human medicine, with nanoparticles (NPs) showing great potential in treating various diseases. The interaction between NPs and proteins plays a crucial role in inhibiting protein aggregation and fibrillation of amyloid proteins. This inhibition represents a new generation of innovative medicines to combat metabolic diseases such as type 2 diabetes. Advances in understanding S-cells and the formation of amylin oligomers and aggregates under diabetic conditions are discussed, and the potential of carbon nanocolloids in reversing protein aggregation is highlighted.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Bikash R. Sahoo, Christopher L. Souders, Takahiro Watanabe-Nakayama, Zhou Deng, Hunter Linton, Saba Suladze, Magdalena I. Ivanova, Bernd Reif, Toshio Ando, Christopher J. Martyniuk, Ayyalusamy Ramamoorthy
Summary: This study demonstrates that synthetic copolymer derivatives can alter amylin aggregation and modulate its conformation, providing insights into the mechanism of amylin pathogenic formation.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Ana F. Raimundo, Sofia Ferreira, Vania Pobre, Mafalda Lopes-da-Silva, Jose A. Brito, Daniel J. V. A. dos Santos, Nuno Saraiva, Claudia N. dos Santos, Regina Menezes
Summary: In this study, a unique collection of (poly)phenol metabolites predicted to appear in the human circulation after ingesting (poly)phenols was examined using a strategy combining in silico, cell-free and cell studies. Urolithin B was identified as a potent inhibitor of IAPP aggregation and a powerful modulator of cell homeostasis pathways.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sanduni Wasana Jayaweera, Solmaz Surano, Nina Pettersson, Elvira Oskarsson, Lovisa Lettius, Anna L. Gharibyan, Intissar Anan, Anders Olofsson
Summary: The study demonstrates that TTR can interfere with IAPP amyloid-formation, prolonging the lag-phase and impairing elongation. The interfering ability correlates inversely with the thermodynamic stability of TTR, but not with kinetic stability. TTR's interference ability remains effective in the low pH environment of IAPP-containing granules, but TTR-stabilizing drugs partially weaken its efficacy.
Article
Biochemistry & Molecular Biology
Anagha C. Unnikrishnan, Ganesh Shanmugam
Summary: The study used VCD technique and isotope labelling strategy to investigate the local structure of IAPf amyloid fibrils, revealing the fibrillar structure at the amino acid residue level and the roles of glycine and phenylalanine.
JOURNAL OF STRUCTURAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shabnam Radbakhsh, George E. Barreto, Abigail R. Bland, Amirhossein Sahebkar
Summary: This review discusses possible mechanisms by which curcumin could interfere with self-assembly processes and reduce amyloid aggregation in amyloidosis, as well as clinical trials in which curcumin is used as a therapeutic agent for diseases linking to protein aggregates.
Review
Engineering, Chemical
Yanxian Zhang, Yijing Tang, Dong Zhang, Yonglan Liu, Jian He, Yung Chang, Jie Zheng
Summary: The research focuses on the mechanism of amyloid cross-seeding between Aβ and hIAPP and its connection between AD and T2D, explores the role of structural compatibility and sequence similarity of amyloid proteins in cross-seeding, and proposes current challenges and future research directions in this less-studied field.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2021)
Review
Food Science & Technology
Raliat O. Abioye, Chibuike C. Udenigwe
Summary: IAPP aggregation plays a crucial role in the development of type 2 diabetes by reducing insulin production and damaging pancreatic beta-cell function. Understanding the structure, function, aggregation mechanism, and inhibitors of IAPP provides insights for better management of T2D.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Review
Biochemistry & Molecular Biology
Andrew Salib, Fritz Cayabyab, Eiji Yoshihara
Summary: The discovery of insulin injection a century ago revolutionized the treatment of diabetes. However, current insulin injection therapy is unable to address the underlying causes of the disease. To achieve long-term treatment and understand the molecular mechanisms of type 2 diabetes, new technologies such as human pluripotent stem cell (hPSC)-derived islets are needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Michalis Michailidis, Despina Moraitou, Despina A. Tata, Kallirhoe Kalinderi, Theodora Papamitsou, Vasileios Papaliagkas
Summary: This review article discusses the shared pathophysiological connections between Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM), emphasizing the role of insulin in the brain and the mechanistic interplay between the two diseases. The findings highlight the need for routine evaluation and treatment of cognitive impairment in T2DM patients and the evaluation of insulin levels or T2DM in AD patients. The hypothesis of AD as a type 3 diabetes is strongly supported.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Ana Garcia-Aguilar, Carlos Guillen
Summary: Diabetes is a complex disease characterized by the increase and subsequent apoptosis of pancreatic beta cells. Various conditions can affect the homeostasis and viability of the beta cells. It has been found that different polyphenols may have regulatory effects on these mechanisms, offering potential for diabetes treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiao Wang, Yushuo Xiao, Chengyu Liu, Yixue Huang, Robert B. Petersen, Ling Zheng, Kun Huang
Summary: MeCP2 plays a crucial role in both neurological and non-neurological disorders, including causing Rett syndrome in the former and cardiac dysfunction, liver injury, respiratory disorders, and other conditions in the latter. Research suggests that MeCP2 can influence various physiological and pathological processes in a DNA methylation-dependent or independent manner.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Review
Medicine, Research & Experimental
Yang Li, Yushuo Xiao, Yuchen Chen, Kun Huang
Summary: Nanotechnology has provided a foundation for developing new antiviral strategies utilizing nanomaterials such as nanodrugs, nanocarriers, and nano-based vaccines. These materials offer diverse antiviral mechanisms at the molecular, cellular, and organismal levels to protect against viral infections effectively. The future prospects for nano-based antiviral agents and vaccines look promising with their potential in improving vaccine efficacy and contributing to immunogenicity.
Article
Cell Biology
Chen Yang, Yu Zhang, Xia Zeng, Huijing Chen, Yuchen Chen, Dong Yang, Ziwei Shen, Xiaomu Wang, Xinran Liu, Mingrui Xiong, Hong Chen, Kun Huang, Haian Fu
Summary: Research has identified KIM1 as a novel receptor for SARS-CoV-2, potentially exacerbating renal infection; KIM1 could be further explored as a therapeutic target.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Review
Cell Biology
Jing Yang, Qiu-yi Song, Shu-xuan Niu, Hui-jing Chen, Robert B. Petersen, Yu Zhang, Kun Huang
Summary: ANGPTLs, a family of secreted glycoproteins, play key roles in lipid metabolism and inflammation. Their potential roles and mechanisms in inflammatory diseases have attracted significant attention from researchers.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shilin Wang, Jiaojiao Zheng, Liang Ma, Robert B. Petersen, Li Xu, Kun Huang
Summary: Protein aggregation is closely related to the development of PMDs, and inhibiting the formation of toxic protein aggregates is seen as a potential therapeutic approach. Nanomaterials have shown promise in this regard, but the precise mechanisms of interaction with amyloidogenic proteins are still not well understood. Rational design strategies must consider factors such as size, charge, concentration, surface modification, and morphology to achieve desired effects on protein aggregation.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Biochemistry & Molecular Biology
Baoshen He, Shijia Kang, Zhen Chen, Xiao Liu, Jinkai Wang, Xuedan Li, Xiaomin Liu, Ling Zheng, Mengcheng Luo, Yan Wang
Summary: Hypercholesterolemia has a strong genetic component, with certain monogenic genes identified for familial hypercholesterolemia. However, in the general population, most individuals with high LDL cholesterol levels do not have known mutations associated with familial hypercholesterolemia. Whole-exome sequencing has identified numerous variants, but the functional consequences of these variants remain largely unknown.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Pharmacology & Pharmacy
Yixue Huang, Yunhao Xie, Dong Yang, Mingrui Xiong, Xingrui Chen, Di Wu, Qing Wang, Hong Chen, Ling Zheng, Kun Huang
Summary: Acetaminophen (APAP) overdose is a major cause of acute liver failure. Recent research suggests that the epigenetic enzyme Utx plays a key role in APAP-induced liver injury by promoting the clearance of toxic metabolites and alleviating ER stress. Additionally, overexpression of Sult2a1 can reduce APAP overdose-induced liver injury.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Immunology
Yunhao Xie, Jin Li, Huan Qin, Qing Wang, Zixi Chen, Chengyu Liu, Ling Zheng, Jiangxin Wang
Summary: The study found that sonicated and alkalized paramylon (SA-Pa) effectively alleviated LPS/D-Gal-induced ALI and promoted M2 macrophage activation, reducing inflammation and cell death in the liver.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Qing Wang, Yuchen Chen, Yunhao Xie, Dong Yang, Yuyan Sun, Yangmian Yuan, Hong Chen, Yu Zhang, Kun Huang, Ling Zheng
Summary: Linker histone H1.2 plays a significant role in hepatocellular carcinoma by regulating the activation of STAT3 and participating in inflammatory response. Blocking the H1.2/STAT3 loop may be a potential strategy for the treatment of hepatocellular carcinoma.
Article
Multidisciplinary Sciences
Hong Chen, Chong Liu, Qian Wang, Mingrui Xiong, Xia Zeng, Dong Yang, Yunhao Xie, Hua Su, Yu Zhang, Yixue Huang, Yuchen Chen, Junqiu Yue, Chengyu Liu, Shun Wang, Kun Huang, Ling Zheng
Summary: The global obesity epidemic has negative effects on human health by causing obesity-related kidney and liver diseases. The researchers found that knockout of the UTX gene inhibits lipid accumulation in the kidney and liver induced by a high-fat diet by increasing circulating serine levels. They also discovered that UTX regulates the degradation of phosphoglycerate dehydrogenase, a key enzyme in serine synthesis, which in turn affects renal and circulating serine levels. Importantly, oral administration of serine improves fatty liver and renal dysfunction induced by a high-fat diet. These findings suggest potential treatment targets for obesity-related metabolic disorders.
NATURE COMMUNICATIONS
(2022)
Review
Nutrition & Dietetics
Chengyu Liu, Wanyao Yan, Jiajian Shi, Shun Wang, Anlin Peng, Yuchen Chen, Kun Huang
Summary: Individuals with obesity have shown worse prognosis and higher mortality in the COVID-19 pandemic. Dyslipidemia, a common condition in obese individuals, plays a major role in the severity of COVID-19. The use of statins, lipid-regulating drugs, has been associated with a reduced risk of progressing to severe illness and in-hospital death in COVID-19 patients. However, caution should be taken due to potential side effects and concerns about interference with COVID-19 vaccines. Further clinical trials are needed to fully understand the benefits, harms, and mechanisms of statin use in the context of COVID-19.
FRONTIERS IN NUTRITION
(2022)
Review
Pharmacology & Pharmacy
Liang Ma, Xi Li, Chengyu Liu, Wanyao Yan, Jinlu Ma, Robert B. Petersen, Anlin Peng, Kun Huang
Summary: Parkinson's disease is a common neurodegenerative disease that affects the motor system and worsens with age. Current treatment options mainly target symptoms due to limited understanding of the disease's causes and mechanisms. Various preclinical models, including C. elegans, have been developed to study the disease and test potential treatments.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Medicine, Research & Experimental
Jiao Wang, Mingrui Xiong, Yu Fan, Chengyu Liu, Qing Wang, Dong Yang, Yangmian Yuan, Yixue Huang, Shun Wang, Yu Zhang, Shuxuan Niu, Junqiu Yue, Hua Su, Chun Zhang, Hong Chen, Ling Zheng, Kun Huang
Summary: This study reveals a protective role of Mecp2 in acute kidney injury (AKI) induced by ischemia-reperfusion, suggesting that it inhibits renal tubular damage, inflammation, and fibrosis by suppressing the Il-6/STAT3 signaling pathway.
