Article
Biochemistry & Molecular Biology
Ya Wang, Yuanbing Yao, Qunhui Wei, Shichao Long, Yuqiao Chen, Jinru Xie, Rong Tan, Wei Jiang, Qian Zhang, Dongbo Wu, Shuai Xiao, Fengyi Wan, Kai Fu
Summary: TRIM24, an oncogene overexpressed in cancers, has been identified as a novel signaling molecule in response to DNA double-strand breaks (DSBs). It promotes the recruitment of the MRN complex and activation of downstream signaling. Depletion of TRIM24 enhances sensitivity to cancer therapy and inhibits tumor growth. This study highlights the potential of TRIM24 as a therapeutic target for tumor treatment.
Article
Biochemistry & Molecular Biology
Raul Garcia-Gonzalez, Eva Monte-Serrano, Patricia Morejon-Garcia, Elena Navarro-Carrasco, Pedro A. Lazo
Summary: This study reveals the role of VRK1 chromatin kinase in the activation of Tip60 and the cooperation between VRK1 and DNA-PK in Tip60 phosphorylation. T158 phosphorylation protects Tip60 from degradation, promotes its recruitment to chromatin, and is necessary for its full activity. S199 phosphorylation directly facilitates Tip60 autoacetylation. These findings are important for understanding the regulatory mechanisms of chromatin remodeling in the DNA damage response.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2022)
Article
Virology
Barbora Lubyova, Eva Tikalova, Kristyna Krulova, Jan Hodek, Ales Zabransky, Ivan Hirsch, Jan Weber
Summary: The molecular connection between the host DDR pathway and HBV replication has been demonstrated, with the roles of ATM and ATR PI3-kinases in HBc phosphorylation investigated. Etoposide and hydrogen peroxide treatment activated the ATM-Chk2 pathway, leading to increased phosphorylation of HBc and potential growth advantage to the replicating virus.
Article
Microbiology
Nujud Almuzaini, Madison Moore, Marjorie Robert-Guroff, Michael A. Thomas
Summary: The study reveals that the viral oncogene E4orf3 plays a role in promoting DNA > 4n in adenovirus-infected cells and may be linked to its oncogenic potential.
MICROBIOLOGY SPECTRUM
(2022)
Review
Immunology
Thomas J. Weitering, Sanami Takada, Corry M. R. Weemaes, Pauline A. van Schouwenburg, Mirjam van der Burg
Summary: ATM is often considered the key regulator of the DNA double-stranded break response, yet patients with ataxia telangiectasia surprisingly exhibit only mild immunodeficiency compared to other DSB repair syndromes. Despite its numerous functions, ATM is not essential for acquiring sufficient levels of immunological diversity to prevent severe infections, although there is a notable antibody deficiency in ataxia telangiectasia patients due to disrupted class switch recombination.
TRENDS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Yang Wang, Tianyu Yu, Yi Han, Yazhi He, Yiran Song, Leiming Guo, Liwei An, Chunying Yang, Feng Wang
Summary: This study reveals the key regulatory role of Mad2 phosphorylation in checkpoint defects and DNA damage repair in ATM-deficient cells. ATM negatively regulates the phosphorylation of Mad2, causing decreased DNA damage repair capacity and resistance to cancer cell radiotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
Yan Jin, Yiting Li, Shiyi He, Yijun Ge, Yun Zhao, Ke Zhu, Andong He, Siyu Li, Siyu Yan, Chao Cao
Summary: PM2.5 induces airway inflammation and DNA damage, and the ATM gene plays a role in promoting this inflammation.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sapir Schlam-Babayov, Ariel Bensimon, Michal Harel, Tamar Geiger, Ruedi Aebersold, Yael Ziv, Yosef Shiloh
Summary: This study conducted a comprehensive phosphoproteomic analysis in human wild-type and A-T cells to reveal the fine-tuned dynamics and relationships between PIKKs in the response to genotoxic stress. The results highlight the complex interactions among ATM, ATR, and DNA-PK in the DDR.
Article
Microbiology
Weiyin Xu, Ping Yan, Ziyan Zhou, Jingting Yao, Haochun Pan, Luyao Jiang, Zongyi Bo, Bo Ni, Mingxia Sun, Song Gao, Changchao Huan
Summary: Pseudorabies virus (PRV) infection in swine can cause high morbidity and mortality, leading to significant economic losses. In this study, the role of histone deacetylase 6 (HDAC6) in PRV infection was investigated. The inhibition of HDAC6 significantly decreased PRV replication, while its overexpression promoted PRV replication. PRV infection induced DNA damage response (DDR), and HDAC6 inhibition and knockout decreased DDR, suggesting that HDAC6 may be a crucial factor in promoting PRV replication.
MICROBIOLOGY SPECTRUM
(2023)
Article
Oncology
Jingjing Zhang, Qiong Wu, Lucheng Zhu, Shujun Xie, Linglan Tu, Yuhong Yang, Kan Wu, Yanyan Zhao, Yuqing Wang, Yasi Xu, Xueqin Chen, Shenglin Ma, Shirong Zhang
Summary: SERPINE2 is identified as a regulator of radiosensitivity and the DNA damage response (DDR) in lung cancer, with knockdown improving tumor radiosensitivity by reducing homologous recombination repair, restoring cell cycle checkpoints, and suppressing migration and invasion. Additionally, high SERPINE2 expression correlates with poor prognosis and a high serum concentration predicts a poor response to radiotherapy in lung cancer patients.
Article
Medicine, General & Internal
Ryoko Horigome, Kenya Kamimura, Yusuke Niwa, Kohei Ogawa, Ken-Ichi Mizuno, Koichi Fujisawa, Naoki Yamamoto, Taro Takami, Tomoyuki Sugano, Akira Sakamaki, Hiroteru Kamimura, Masaaki Takamura, Shuji Terai
Summary: The DSS-induced colitis mouse model causes colon shortening and increased disease activity index, while also activating the Atm-Chk2 pathway and inducing cell apoptosis at the cellular level. Knockout mice lacking the Ccndbp1 gene exhibit better protection against DSS-induced colitis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Salim Abdisalaam, Shibani Mukherjee, Souparno Bhattacharya, Sharda Kumari, Debapriya Sinha, Janice Ortega, Guo-Min Li, Hesham A. Sadek, Sunil Krishnan, Aroumougame Asaithamby
Summary: NBS1 protein, in coordination with ATM and CtIP, functions as an upstream regulator that prevents cGAS from binding micronuclear DNA. Cells lacking NBS1 recruit cGAS to micronuclear DNA and activate its function.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Cell Biology
Pengyi Yan, Zixuan Li, Junhao Xiong, Zilong Geng, Weiting Wei, Yan Zhang, Gengze Wu, Tao Zhuang, Xiaoyu Tian, Zhijie Liu, Junling Liu, Kun Sun, Fengyuan Chen, Yuzhen Zhang, Chunyu Zeng, Yu Huang, Bing Zhang
Summary: In this study, LARP7 is identified as an aging antagonist, and the ATM-LARP7-SIRT1-p53/p65 pathway plays a crucial role in DNA damage response-mediated cellular senescence and atherosclerosis.
Article
Oncology
Xiaoqing Zhang, Matias A. Bustos, Rebecca Gross, Romela Irene Ramos, Teh-Ling Takeshima, Gordon B. Mills, Qiang Yu, Dave S. B. Hoon
Summary: Our study reveals that ILF2 amplification on chromosome 1q21.3 is linked to melanoma progression and activates a downstream pathway in metastatic melanoma that increases drug resistance. ILF2 expression is positively correlated with copy number variation and is associated with poor overall survival in metastatic melanoma patients. Overexpression of ILF2 promotes cell proliferation in metastatic melanoma, while knockdown of ILF2 inhibits proliferation by blocking the cell cycle.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Editorial Material
Genetics & Heredity
Hartwig Visser, Adam D. Thomas
Summary: DNA damage-induced miRNAs are important in the DNA damage response, influencing cell fate. However, it is still unclear who is in charge in this process.
TRENDS IN GENETICS
(2021)
