期刊
FEBS LETTERS
卷 583, 期 21, 页码 3519-3524出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2009.10.014
关键词
Long-chain polyamine; Archaea; Polyamine synthesis; Hyperthermus butylicus; Pyrobaculum aerophilum
Polyamines are ubiquitously present in all organisms. In addition to the common polyamines, thermophilic archaea synthesize long-chain polyamines. In the present study polyamine synthases from Hyperthermus butylicus and Pyrobaculum aerophilum were cloned and their substrate specificity was analyzed. The polyamine synthase HbSpeE II from H. butylicus synthesized long-chain polyamines with high activity using the same mechanism that is used by a wide range of organisms to synthesize common polyamines, in which the aminopropyl residue derives from decarboxylated S-adenosylmethionine. This is the first polyamine synthase described that synthesizes a polyamine longer than a tetramine with high activity. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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