期刊
FEBS LETTERS
卷 584, 期 2, 页码 434-442出版社
WILEY
DOI: 10.1016/j.febslet.2009.11.064
关键词
Aminoacyl-tRNA synthetase; Non-canonical function; Human; Structure; Multisynthetase complex; Disease
资金
- National Institutes of Health [GM 15539, GM 23562, U54RR025204]
- National Cancer Institute [CA92577]
- National Foundation for Cancer Research
Known as an essential component of the translational apparatus, the aminoacyl-tRNA synthetase family catalyzes the first step reaction in protein synthesis, that is, to specifically attach each amino acid to its cognate tRNA. While preserving this essential role, tRNA synthetases developed other roles during evolution. Human tRNA synthetases, in particular, have diverse functions in different pathways involving angiogenesis, inflammation and apoptosis. The functional diversity is further illustrated in the association with various diseases through genetic mutations that do not affect aminoacylation or protein synthesis. Here we review the accumulated knowledge on how human tRNA synthetases used structural inventions to achieve functional expansions. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据