期刊
FEBS LETTERS
卷 583, 期 17, 页码 2710-2714出版社
WILEY
DOI: 10.1016/j.febslet.2009.07.021
关键词
Mdmx; Mdm2; p53; Ubiquitination
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Ministry of Health, Labor and Welfare, Japan
- Foundation for Promotion of Cancer Research
mdm2 and mdmx oncogenes play essential yet non-redundant roles in synergistic inactivation of the tumor suppressor, p53. While Mdm2 inhibits p53 activity mainly by augmenting its ubiquitination, the functional role of Mdmx on p53 ubiquitination remains obscure. In transfected H1299 cells, Mdmx augmented Mdm2-mediated ubiquitination of p53. In in vitro ubiquitination assays, the Mdmx/Mdm2 heteromeric complex, in comparison to the Mdm2 homomer, showed enhanced ubiquitinase activity toward p53 and the reduced auto-ubiquitination of Mdm2. Alteration of the substrate specificity via binding to Mdmx may contribute to efficient ubiquitination and inactivation of p53 by Mdm2. Structured summary: MINT-7219995: P53 (uniprotkb: P04637) physically interacts (MI: 0914) with Ubiquitin ( uniprotkb: P62988) by anti bait coimmunoprecipitation ( MI: 0006) MINT-7220023: Ubiquitin ( uniprotkb: P62988) physically interacts ( MI: 0914) with P53 ( uniprotkb: P04637) by pull down ( MI: 0096) (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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