Review
Neurosciences
Rodrigo C. Meza, Carlos Ancaten-Gonzalez, Chiayu Q. Chiu, Andres E. Chavez
Summary: This article discusses the roles of TRPV1 in both central and peripheral systems, exploring its regulation of synaptic function and potential therapeutic applications.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Immunology
Siri Tahtinen, Ann-Jay Tong, Patricia Himmels, Jaehak Oh, Andres Paler-Martinez, Leesun Kim, Sara Wichner, Yoko Oei, Mark J. McCarron, Emily C. Freund, Zhainib Adel Amir, Cecile C. de la Cruz, Benjamin Haley, Craig Blanchette, Jill M. Schartner, Weilan Ye, Mahesh Yadav, Ugur Sahin, Lelia Delamarre, Ira Mellman
Summary: Lipid-formulated RNA vaccines can cause systemic inflammatory responses in humans, which were not predicted in preclinical studies. The IL-1 pathway plays a key role in triggering vaccine-induced inflammation, but this effect is dampened in mice.
Article
Medicine, Research & Experimental
Hideki Sakatani, Masamitsu Kono, Tatsuya Shiga, Hiroki Kuwazoe, Denisa Nanushaj, Ibu Matsuzaki, Shin-Ichi Murata, Masayasu Miyajima, Yuka Okada, Shizuya Saika, Muneki Hotomi
Summary: Olfactory disorders, closely related to cognitive deterioration, can be caused by infections, aging, and environmental chemicals. This study focused on the involvement of TRPV1 and TRPV4 channels in olfactory receptor neuron (ORN) regeneration, demonstrating that TRPV1 stimulates progenitor cell proliferation while TRPV4 regulates proliferation and maturation, suggesting their essential roles in ORN regeneration.
LABORATORY INVESTIGATION
(2023)
Review
Pharmacology & Pharmacy
Cigdem Yucel, Gokce Seker Karatoprak, Ozlem Bahadir Acikara, Esra Kupeli Akkol, Timur Hakan Barak, Eduardo Sobarzo-Sanchez, Michael Aschner, Samira Shirooie
Summary: Ginger is a popular spice and medicinal plant, containing phenolic compounds such as gingerols. Gingerols have antioxidant, anti-inflammatory, and immune-modulating properties. However, low bioavailability is a challenge, and new drug delivery systems have been developed to enhance the effectiveness of gingerols.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yaxin Lou, Yangqiu Liu, Jiange Zhao, Weiping Tian, Na Xu, Chengcheng Zang, Kehua Que
Summary: The study revealed that TRPA1 and TRPV1 channels are up-regulated during the odontogenic differentiation of HDPCs and can affect odontogenic differentiation by regulating intracellular Ca2+ concentration, leading to increased mineralization levels and expression of odontogenic markers.
JOURNAL OF ENDODONTICS
(2021)
Article
Biochemistry & Molecular Biology
Jing Hu, Mengkang Gao, Yang Zhang, Yusui Wang, Zhenrui Qiao, Weiya Zhang, Qiang Wang, Lin Yan, Hai Qian
Summary: In this study, three series of new piperazine urea TRPV1 antagonists were designed, synthesized, and evaluated, among which compound 5ac showed excellent TRPV1 antagonistic activity, good bioavailability, and no hyperthermia side effects. The molecular docking study revealed that compound 5ac interacted well with the amino acid residues on rTRPV1 through hydrophobic interaction, making it an efficient TRPV1 antagonist and a potential candidate for analgesic drug development.
BIOORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Sung-Min Hwang, Youn-Yi Jo, Cinder Faith Cohen, Yong-Ho Kim, Temugin Berta, Chul-Kyu Park
Summary: This review focuses on the mechanisms by which venom-derived peptides interact with the outer pore region of TRPV1 to control receptor functions and how these mechanisms can drive the development of new types of analgesics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fangjie Jin, Yuting Wen, Guoqiang Lin, Shaopeng Yu, Chao Wang, Wenbo Ye, Jiange Zhang
Summary: Pain-relief is a long-term research topic with high clinical demand. TRPV1 has been identified as a potential target for the development of analgesic agents. A series of novel TRPV1 agonists, based on Cannabidiol, were designed and synthesized, with compound 10f showing promising TRPV1 agonistic activity, higher target affinity, stronger analgesic activity, and weak side effects.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Review
Physiology
Guangxin Peng, Xiaoling Tang, Yang Gui, Jing Yang, Lifang Ye, Liuyang Wu, Ya Hui Ding, Lihong Wang
Summary: TRPV1 plays a significant role in fibrotic diseases, regulating the fibrotic processes and potentially serving as a therapeutic target.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Immunology
Lin Shang, Siqi Zhao, Huijuan Shi, Xinzhu Xing, Jingya Zhang, Yanling He
Summary: Pruritus is a common and painful symptom in psoriasis that greatly affects quality of life. Neurogenic inflammation induced pruritus is the predominant mechanism in psoriasis, with the nerve growth factor (NGF)-mediated TRPV1 pathway playing a crucial role. However, the development of systemic TRPV1 antagonists has been hindered by elevated core temperature. Therefore, topical application of TRPV1 antagonists and interference with TRPV1 activation pathway mediators could be promising therapeutic options. This review focuses on recent advances in understanding the complex regulation of the NGF-mediated TRPV1 pathway in psoriatic pruritus and the potential therapeutic approaches derived from this knowledge.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Qiqi Yan, Jun Tang, Xin Zhang, Liuyang Wu, Yunyi Xu, Lihong Wang
Summary: TRPV1 channel plays a beneficial role in heart diseases, but the specific mechanism in pathological myocardial hypertrophy remains unclear, posing a research gap. The study aims to provide new treatment targets for pathological myocardial hypertrophy by summarizing the role and mechanism of TRPV1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ping-Chung Kuo, Yue-Chiun Li, Anjar M. Kusuma, Jason T. C. Tzen, Tsong-Long Hwang, Guan-Hong Ye, Mei-Lin Yang, Sheng-Yang Wang
Summary: This study isolated and characterized five undescribed compounds and seventy-two known compounds from P. taiwanensis needles, with six compounds showing significant anti-inflammatory bioactivity. Among them, compounds 49, 50, and 51 were found to form stable complexes with the ghrelin receptor through hydrogen bonds and different types of interactions, indicating flavonoids may be responsible for the potential anti-aging effects of pine needle tea.
Article
Neurosciences
Tao Zhang, Yuan Tian, Xiaoqing Zheng, Ruomeng Li, Li Hu, Xindong Shui, Yingxue Mei, Quling Wang, Mi Zhang, Xiuzhi Zheng, Long Wang, Dongmei Chen, Wucheng Tao, Tae Ho Lee
Summary: This study found that capsaicin can promote autophagy and reduce the abnormal accumulation of tau protein by activating the TRPV1 channel, thereby improving synaptic damage and cognitive impairment. Experimental validation showed that this effect is mediated by the AMPK/mTOR signaling pathway. The results of this study reveal the role of capsaicin in restoring tau protein homeostasis through modulating cellular autophagy and support the potential of TRPV1 as a therapeutic target for tauopathies.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Lingfeng Zhang, Yantao Xu, Yingxu Ma, Tianjian Xie, Chan Liu, Qiming Liu
Summary: This article provides a bibliometric analysis of the relationship between transient receptor potential vanilloid (TRPV) and cardiovascular system disease. The findings show significant growth in the field since 2008, with the United States and China in dominant positions. The study suggests the need for intercontinental cooperation and future research on pharmacological mechanisms and new clinical disease application areas.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Hideaki Yamada, Naoaki Sakata, Tomoko Tanaka, Hideaki Tagashira, Gumpei Yoshimatsu, Ryo Kawakami, Hideichi Wada, Takahiro Iwamoto, Shohta Kodama
Summary: This study showed that activating TRPV4 can improve blood flow in the ischemic hindlimb animal model by promoting both angiogenesis and lymphangiogenesis. It suggests that upregulating both lymphatic and blood vessels through TRPV4 activation could be a promising therapeutic strategy for peripheral artery disease.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Balazs Kelemen, Silvia Pinto, Nawoo Kim, Erika Lisztes, Martin Hanyicska, Anita Vladar, Attila Olah, Zsofia Penzes, Brian Shu, Joris Vriens, Tamas Biro, Tibor Rohacs, Thomas Voets, Balazs Istvan Toth
Summary: TRPM3 selectively mediates pain sensation but not itch sensation, making it a promising candidate for selectively targeting pain sensation.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Erika Lisztes, Erika Mezo, Fruzsina Demeter, Lilla Horvath, Szilvia Bosze, Balazs Istvan Toth, Aniko Borbas, Mihaly Herczeg
Summary: The study focused on synthesizing non-glycosaminoglycan, heparin-related trisaccharides with high anticancer activity. Partially methylated compounds showed significant inhibitory effects on ovarian carcinoma and melanoma cells, while acetyl substituents were beneficial to cytostatic activity of the sulfated derivatives.
Review
Cell Biology
Katharina Held, Balazs Istvan Toth
Summary: Ion channels play a crucial role in regulating neural processes in the brain, and disruptions in their functions can lead to various neurological disorders. TRP ion channels are key players in the development and physiological functions of the central nervous system, influencing processes like neurite growth and synaptic plasticity. TRPM3, a non-selective cation channel, is emerging as a new player in the brain with potential roles in neuropathological processes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Agnes Angyal, Zsofia Penzes, Shahrzad Alimohammadi, Dorottya Horvath, Lili Takacs, Gyorgy Vereb, Barbara Zsebik, Tamas Biro, Kinga Fanni Toth, Erika Lisztes, Balazs Istvan Toth, Attila Olah, Attila Gabor Szollosi
Summary: The study found that human corneal epithelial cells express members of the endocannabinoid system, playing a role in inflammatory responses. Despite previous reports on the anti-inflammatory potential of endocannabinoids, their effects on the immune phenotype of human corneal epithelium may be more complex and context dependent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Nikolett Vasas, Zsofia Penzes, Kornel Kistamas, Peter Pal Nanasi, Szabolcs Molnar, Andrea Szegedi, Attila Gabor Szollosi, Tamas Biro
Summary: TRPV3, a pro-inflammatory ion channel, is significantly upregulated in the skin of atopic dermatitis patients. This study provides the first evidence of TRPV3 expression and function in non-lesional AD skin.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Biology
Dora Antal, Shahrzad Alimohammadi, Peter Bai, Attila Gabor Szollosi, Magdolna Szanto
Summary: This review discusses the functional specialization of human skin APCs that promote T cell activation and adaptive immune response during the initiation and onset of psoriasis.
Review
Biochemistry & Molecular Biology
Dorottya Adam, Jozsef Arany, Kinga Fanni Toth, Balazs Istvan Toth, Attila Gabor Szollosi, Attila Olah
Summary: Atopic dermatitis is a common skin disease, especially prevalent among children. Although there have been advancements in understanding its pathogenesis, curative treatments are still lacking. Therefore, it is important to further investigate the mechanisms and explore new therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Attila Gabor Szollosi, Attila Olah, Erika Lisztes, Zoltan Griger, Balazs Istvan Toth
Summary: Pruritus, or itch, is a common symptom associated with various skin and immune disorders. Despite significant progress in understanding the molecular mechanisms behind acute and chronic itch, there are still gaps in our knowledge, making the clinical management of pruritic conditions challenging. Recent research has highlighted the interactions between pruriceptive sensory neurons and different cutaneous cell types, particularly in inflammatory conditions, where these cells release mediators that excite the itch-sensing fibers. There is also bidirectional communication, with sensory neurons releasing mediators that maintain an inflamed and itchy tissue environment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Xufeng Huang, Hafiz Muzzammel Rehman, Attila Gabor Szollosi, Shujing Zhou
Summary: This study utilizes network pharmacology and bioinformatic analysis to unravel the potential mechanisms of curcumol against hepatocellular carcinoma (HCC). The findings provide reference for further experimental studies and present a roadmap for in silico prescreening of other compounds of interest.
Article
Dermatology
Shahrzad Alimohammadi, Zsofia Penzes, Dorottya Horvath, Agnes Gyetvai, Attila Bacsi, Nikoletta Greta Kis, Akos Nemeth, Jozsef Arany, Attila Olah, Erika Lisztes, Balazs Istvan Toth, Tamas Biro, Attila Gabor Szollosi
Summary: This study compared the transcriptome of monocyte-derived Langerhans cells (moLCs) with that of immature dendritic cells using RNA sequencing. The results showed that moLCs express genes characteristic of LC2 cells and TRPV4. Activation of TRPV4 increased the expression of Langerin and intracellular calcium concentration in moLCs. Furthermore, TRPV4 activation mitigated the inflammatory responses of moLCs by decreasing cytokine production and T-cell activating capability.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Spectroscopy
Petra Pal, Miklos Veres, Roman Holomb, Melinda Szaloki, Istvan Csarnovics, Attila Gabor Szoellosi
Summary: Metal ions, like nickel, are strongly bound to amino acids and form metal complexes with different geometric structures. The formation of histidine-nickel (II) complex was examined under different conditions using Raman spectroscopy. Additionally, density functional theory calculations were performed to understand the formation mechanism and optimal geometry of the complex. The Raman measurements showed specific peaks that belong to the metal complex. The alkaline pH favored complex formation, while the concentration of metal ions had no effect on the formation of the histidine-nickel (II) complex.
JOURNAL OF RAMAN SPECTROSCOPY
(2023)
Article
Oncology
Shujing Zhou, Attila Gabor Szollosi, Xufeng Huang, Yi-Che Chang-Chien, Andras Hajdu
Summary: In this study, a machine learning-based prognostic model was developed for accurate survival prediction in pancreatic adenocarcinoma (PAAD) patients. The findings also provided insights into the tumor immunological microenvironment and potential therapeutic strategies.
Review
Health Care Sciences & Services
Monica Neagu, Carolina Constantin, Gheorghita Jugulete, Victor Cauni, Sandrine Dubrac, Attila Gabor Szollosi, Sabina Zurac
Summary: Langerhans cells (LCs) play vital roles in the immune response of the skin, including activation of adaptive immune cells and participation in anti-cancer immune reactions. Therefore, studying the immune properties of these cells is of great value for the treatment of skin pathologies, especially cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Shahrzad Alimohammadi, Kana Masuda-Kuroki, Attila Gabor Szollosi, Anna Di Nardo
Summary: This research study revealed significant differences in marker expressions of human cord blood-derived mast cells (hCBMCs) based on donor dependency and the type of medium used for culturing and differentiation. The findings emphasize the importance of considering both donor dependency and the medium in studying mast cell functions, and further research is needed to fully understand the impact of these factors on marker expressions of hCBMCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
