期刊
FEBS LETTERS
卷 583, 期 19, 页码 3158-3164出版社
WILEY
DOI: 10.1016/j.febslet.2009.09.002
关键词
Warts family; Ce-wts-1; TGF-beta; Development; Membrane; Caenorhabditis elegans
资金
- National Institutes of Health
- Ministry of Science and Technology of China [2007CB946900, 2007CB946904]
The Hippo-Warts pathway defines a novel signaling cascade involved in organ size control and tumor suppression. However, the developmental function of this pathway is less understood. Here we report that the Caenorhabditis elegans homolog of Warts, Ce-wts-1, plays important roles during worm development. The null allele of Ce-wts-1 causes L1 lethality. Partial loss of Ce-wts-1 function by RNAi reveals that Ce-wts-1 is involved in many developmental processes such as larval development, growth rate regulation, gut granule formation, pharynx development, dauer formation, life-span and body length control. Genetic analyses show that Ce-wts-1 functions synergistically with the TGF-beta Sma/Mab pathway to regulate body length. In addition, CE-WTS-1::GFP is enriched near the inner cell membrane, implying its possible membrane-related function. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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