期刊
FEBS LETTERS
卷 584, 期 3, 页码 567-570出版社
WILEY
DOI: 10.1016/j.febslet.2009.11.098
关键词
Cyclic chalcone analogue; Mitochondria; Respiration; Glutathione; Oxidative stress; Hydroxyl radical
资金
- Slovak Grant Agency for Science [1/0624/08]
- Faculty of Medicine Research Fund, University of Pecs
L We investigated the effect of hydroxyl substituted chalcone (1a) and some chalcone analogues (1b-d) on isolated rat liver mitochondria to gain new insights into the cytotoxic mechanism of these compounds. We observed an inhibitory effect on phosphorylation and the partial uncoupling of compounds 1a and 1d. Increased radical generation and possible covalent interaction of the compounds with cellular thiols resulted in glutathione (GSH) depletion and modulation of the investigated mitochondrial activities. Disruption of interconnected mechanisms as electron transport chain and energetic metabolism, ROS production and insufficiency of antioxidant defensive system could lead to induction of cell death. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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