☆ 4.5 Article

Investigating the nucleic acid interactions and antimicrobial mechanism of buforin II

FEBS LETTERS (2008)

期刊

FEBS LETTERS

卷 582, 期 12, 页码 1715-1718

出版社

WILEY

DOI: 10.1016/j.febslet.2008.04.036

关键词

histone-derived antimicrobial peptide; buforin II; parasin; hipposin; peptide-DNA interaction; molecular dynamics

类别

Biochemistry & Molecular Biology Biophysics Cell Biology

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Reagent

摘要

Buforin II (BF2) is an antimicrobial peptide that is hypothesized to kill bacteria by entering cells and binding nucleic acids. To further investigate this proposed mechanism, we used computer modeling and experimental measurements to consider the interactions between BF2 and DNA. Computational and experimental results imply that the peptide forms specific interactions with DNA. Moreover, we observe a general correlation between DNA affinity and antimicrobial activity for a series of BF2 variants. Thus, our results support the proposed mechanism for BF2 and provide a useful approach for evaluating the nucleic acid interactions of other antimicrobial peptides. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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