期刊
FEBS LETTERS
卷 582, 期 20, 页码 2985-2992出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.07.046
关键词
cytokines; IL-22R1; IL-22; interleukins; immunology; X-ray crystallography
资金
- FAPESP [06/00182-8, 06/01534-5, 06/60860-0]
- CNPq [154559/2006-7, 473875/2003-9]
- CAPES
- Belgian Federal Service for Scientific, Technical, and Cultural Affairs
- Actions de Recherche Concertees of the Communaute Francaise de Belgique
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [06/01534-5, 06/00182-8] Funding Source: FAPESP
Interleukin-22 (IL-22) is a member of the interleukin-10 cytokine family, which is involved in anti-microbial defenses, tissue damage protection and repair, and acute phase responses. Its signaling mechanism involves the sequential binding of IL-22 to interleukin-22 receptor 1 (IL-22R1), and of this dimer to interleukin-10 receptor 2 (IL-10R2) extracellular domain. We report a 1.9 A crystal structure of the IL-22/IL-22R1 complex, revealing crucial interacting residues at the IL-22/IL-22R1 interface. Functional importance of key residues was confirmed by site-directed mutagenesis and functional studies. Based on the X-ray structure of the binary complex, we discuss a molecular basis of the IL-22/IL-22R1 recognition by IL-10R2.
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